The Application of Facilitated Ion Transfer Across Membrane Stabilized Interface Between tow Immiscible Electrolyte Solutions in Clinical Analysis
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Date
1994-06
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Addis Ababa Universty
Abstract
AC and DC voltammetry and flow injection amperometry methods
were employed in this work. The influence of ionophores on the
facilitated transfer of K+ and Na+ ions across membrane
stabilized water/nitrobenzene interface was investigated.
According to this investigation benzo 15 crown 5 (B15C5) was
found best for K+ ion and dibenzo 24 crown 8 (DB24C8) for Na+.
B15C5 was an appropriate ionophore in simultaneous
determination of K+ and Na+ ions. DB24C8 was found to be poor
in this regard. Stability constants of metal-ionophore complex
were estimated. The values forK+ -ionophore (K-DB24C8, KDB18C6)
were in good agreement with literature values, while
those of Na+-ionophores (Na-DB24C8, Na-DB18C6) are higher than
the literature values. Concentrations of Na+ and K+ in blood
serum were determined simultaneously using flow injection
amperometry and flame photometry. The results obtained from
voltammetric and flow injection amperometric investigations
indicate that the membrane stabilized interface is a promising
as a voltammetric sensor in clinical analysis of blood
electrolytes
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Keywords
AC and DC Voltammetry