A Community Based Randomized Trial of Three Modes of Oral Rehydration Therapy
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Date
1991-03
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Addis Ababa University
Abstract
A randomized field trial of the relative efficacy of
three oral rehydration therapies (ORT) was carried out in
18 rural peasant associations of Adamaboset district,
Ethiopia. The three ORTs were pre-packaged glucose oral
rehydration salt (GORS) solution (n= 153), home made
cereal based roared duration pre packaged sait (cbor) solution (n=154), and home made cereal and salt based
oral rehydration therapy (CBORT) solution (n=156).
CBORT was superior (p<. 01) to GORS and CBORS in
terms of mean weight gain and diminished stool frequency
at 24, 48, and 96 hours following onset of therapy .
Analysis of hydration status indicated a higher
proportion of children receiving CBORT were found in both
the deterioration and improvement categories at 4 hours,
but mean dehydration status at 4, 24, 48 and 96 hours was
no statistically different among ORT groups. Mothers'
compliance was significantly (p<.05) higher and
children's acceptance not statistically different between
those receiving CBORT when compared to GORS and CBORS.
The non-packaged CBORT therapy was found to be as or more
efficacious than GORS or CBORS in the treatment of acute
childhood diarrhoea. On the basis of these findings it
is recommended that replication studies of the relative
effectiveness of CBORT, particularly in comparison with
CBORS, be done with the view of eventually adding CBORT
to ORT programs.
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Community Based Randomized Trial