Worsening Renal Function in Patients Admitted With Acute Decompensated Heart Failure: Incidence and Risk Factors Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia, 2021: A Prospective Study
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Date
2021-10
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Addis Abeba University
Abstract
Background: acute kidney injury and worsening of renal function is common in patients with
acute decompensated heart failure, and development of this entity affects patient’s morbidity
and mortality.
Objectives: The main objective of this study was to assess the prevalence, and associated
factors for development of WRF in admitted ADHF patients.
Methods: This was a prospective, hospital-based study of cardiac patients admitted to TASH
between June, 2021 and October, 2021. A structured questionnaire was used to collect
parameters on sociodemographic characteristics, comorbidities and clinical profile of
patients. Trained physician data clerks collected the data from the chart, interview and
electronic medical records. Data was entered into SPSS version 26 for analysis. Bivariate and
multivariate binary logistic regression analyses was done to identify factors associated with
AKI and WRF, Statistical significance was considered at the level of significance of 0.05%, and
adjusted odds ratio (AOR) with 95% confidence interval (CI) was used to present the
estimates of the strength of the association.
Result: A total of 104 patients were included in the study. 64(61.5%) were male and 40(38.5)
were female. The prevalence of AKI was 21.2% and the prevalence of WRF was 37.5%. The
odds of developing AKI in smokers was 3.7 times higher [AOR= 3.7; 95% CI: (0.86, 13.18)].
Conclusion: This study demonstrated that WRF is frequent finding complicating
management of ADHF patients.