Prevalence of Breakthrough Urinary Tract Infection among Patient on Prophylactic Antibiotics for Recurrent UTI on Follow up at Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopa.
| dc.contributor.advisor | Getache Semhal | |
| dc.contributor.advisor | Abebe Bezaye | |
| dc.contributor.author | Merga Gelassa | |
| dc.date.accessioned | 2025-08-13T07:49:18Z | |
| dc.date.available | 2025-08-13T07:49:18Z | |
| dc.date.issued | 2023-06 | |
| dc.description.abstract | Background: Urinary tract infections (UTIs) are the most common infectious diseases diagnosed around the globe, particularly in developing countries. It is one of the most common microbial diseases encountered in medical practice. Risk factor for Recurrent UTI can be Anatomic factors, toileting habits, constipation, and other factors may contribute to an elevated risk of reinfection. Vesicoureteral reflux (VUR), urinary obstruction, or bladder and bowel dysfunction (BBD) are some of anatomical factor that predispose to recurrent UTI. Objectives: To assess the prevalence of breakthrough urinary tract infection among patient on prophylactic antibiotics for recurrent UTI on follow up at Tikur Anbessa specialized hospital Methods: This study was conducted using a hospital-based Cross-sectional study design from August 2023 to January 2024 at Tikur Anbessa specialized Hospital Renal, Neurology and Pediatric surgical follow-up unit. The sample size required was 277. Data was entered into Statistical Package for Social Sciences version 25 (SPSS) for subsequent descriptive and analytical statistics where applicable. Statistically, a significant association was taken for a p value of Background: Urinary tract infections (UTIs) are the most common infectious diseasesdiagnosed around the globe, particularly in developing countries. It is one of the most commonmicrobial diseases encountered in medical practice. Risk factor for Recurrent UTI can beAnatomic factors, toileting habits, constipation, and other factors may contribute to an elevatedrisk of reinfection. Vesicoureteral reflux (VUR), urinary obstruction, or bladder and boweldysfunction (BBD) are some of anatomical factor that predispose to recurrent UTI. Objectives: To assess the prevalence of breakthrough urinary tract infection among patient onprophylactic antibiotics for recurrent UTI on follow up at Tikur Anbessa specialized hospital Methods: This study was conducted using a hospital-based Cross-sectional study design fromAugust 2023 to January 2024 at Tikur Anbessa specialized Hospital Renal, Neurology andPediatric surgical follow-up unit. The sample size required was 277. Data was entered intoStatistical Package for Social Sciences version 25 (SPSS) for subsequent descriptive andanalytical statistics where applicable. Statistically, a significant association was taken for a p-value of <0.05. Result: The overall prevalence of BUTI was 27%. The average age was 1-4 years of age and74.2% were males. 35.3% of the male participant were uncircumcised. The most common indication for prophylactic antibiotic was CAKUT. 69.2% of the children were on prophylactic antibiotic for more than 12 months. 91.2% of the children in the study used trimethoprim sulfamethoxazole as prophylactic. The most common etiology identified was E.coli (42%).Males that were uncircumcised, neurogenic bladder and urine WBC more than 5 were associated with increased risk for recurrent UTI. 37% of the organism that grew were resistant to more than 3 classes of antibiotics. 70% of the organisms that grew were resistant to trimethoprim sulfamethoxazole. Conclusion: our finding revealed that there is significant burden of breakthrough UTI and uncircumcised male children, neurogenic bladder are higher risk for breakthrough UTI and there is high resistance pattern for the most commonly used antibiotic in our setup which is Trimethoprim-Sulfamethoxazole | |
| dc.identifier.uri | https://etd.aau.edu.et/handle/123456789/6664 | |
| dc.language.iso | en_US | |
| dc.publisher | Addis Ababa University | |
| dc.subject | Urinary tract infections Patient | |
| dc.title | Prevalence of Breakthrough Urinary Tract Infection among Patient on Prophylactic Antibiotics for Recurrent UTI on Follow up at Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopa. | |
| dc.type | Thesis |