The Risk factors for Osteoporosis and Falls, their Association, and Knowledge in Patients with Type 1 Diabetes Mellitus
| dc.contributor.advisor | Feleke,Yeweyenhareg(Prof.) | |
| dc.contributor.author | Efrem,Paulos | |
| dc.date.accessioned | 2024-11-28T09:53:42Z | |
| dc.date.available | 2024-11-28T09:53:42Z | |
| dc.date.issued | 2023-12 | |
| dc.description.abstract | Background: Patients with type 1 diabetes have a lower bone mineral density (BMD) and up to 6-fold higher risk of fracture compared to healthy subjects, justifying the classification of the disease as a non-modifiable risk factor for osteoporosis. The literature describes a variety of risk factors for low BMD in patients with type 1 diabetes, with some conflicting evidence. Data on osteoporosis and related factors in patients with type 1 diabetes in Ethiopia, Africa, and other low- and middle-income countries is lacking. Objectives: To determine the risk factors for osteoporosis and falls, their association, and knowledge in patients with Type 1 Diabetes age 40 years and above. Methods: An institution-based cross-sectional study was conducted from June 1 to August 31, 2023GC at the diabetes clinic in Tikur Anbessa Specialized Hospital, Addis Ababa. All patients with Type 1 diabetes age 40 years and above attending the diabetes clinic during 2023GC were enrolled. Data was collected through pretested structured interviewer-administered questionna ires and analyzed using SPSS version 26. The statistical association was tested using Pearson's correlation coefficient, chi-square test, bivariate and multivariable logistic regression. Statistica l significance was considered at a level of significance of 5%, and an adjusted odds ratio (AOR) with a 95% confidence interval (CI) was used to present the estimates of the strength of the association. Finally, outcomes were presented with tables, figures, and statements. Results: This study involved a total of 106 participants of which 54.7% were males and 47.2% were between the ages of 40-44 years. Ninety-six percent of the study participants were living with Diabetes for more than 10 years and two-thirds had persistent proteinuria. Fifty-two percent had diabetic eye complications, 10.4% had an eGFR of <60ml/min/1.73m2 while 9.4% of the participants consumed more than three units of alcohol per day. Only two participants had a high FRAX fracture risk score but 13.2% had a history of previous fragility fracture. Age and duration of diabetes had a positive correlation and eGFR had a negative one with the 10-year probability of a major osteoporosis-related and hip fracture. The magnitude of osteoporosis was 15%. Fifteen percent of the study participants had frequent falls and 13.2% had a high concern of falling. Being female (AOR=1.6, 95% CI=1.42, 5.88), having previous fragility fractures (AOR=1.8, 95% CI=1.04, 9.27), and osteoporosis (AOR=4.1, 95% CI=1.15, 16.49) were associated with frequent falls. Eighty-three percent had poor knowledge about osteoporosis with a higher level of education associated with a higher level of osteoporosis knowledge. The factors associated with osteoporosis 10 were female gender (AOR=1.8, 95% CI=1.41, 7.69), excess alcohol use (AOR=5.7, 95% CI=1.69, 47.38), diabetic eye complications (AOR=4.7, 95% CI=1.91, 24.35), and frequent falls (AOR=5.6, 95% CI=1.19, 26.15). Conclusion: Type 1 diabetes carries an increased risk of osteoporosis, falls, and fractures. Being female, having previous fragility fractures and osteoporosis had a positive association with frequent falls, whereas being female, excess alcohol use, diabetic eye complications, and frequent falls were independent determinants of osteoporosis. A significant osteoporosis knowledge deficit was also seen among the participants with a higher level of education being positively associated. A high concern of falling with difficulties maintaining balance were other concerning outcomes. | |
| dc.identifier.uri | https://etd.aau.edu.et/handle/123456789/3751 | |
| dc.language.iso | en_US | |
| dc.publisher | Addis Ababa University | |
| dc.subject | Type 1 Diabetes | |
| dc.subject | Osteoporosis | |
| dc.subject | Falls | |
| dc.subject | FRAX | |
| dc.subject | Osteoporosis knowledge | |
| dc.title | The Risk factors for Osteoporosis and Falls, their Association, and Knowledge in Patients with Type 1 Diabetes Mellitus | |
| dc.type | Thesis |