Performance Evaluation of Cell-Dyn 1800 and Sysmex Kx-21 Hematology Analyzers at St. Paul’s Hospital Millennium Medical College, Addis Ababa, Ethiopia
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Date
2015-06
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Addis Ababa University
Abstract
Background: To assure the accuracy of results and performance of hematology analyzers, each
laboratory must evaluate their performance. Different models of Sysmex and Cell- Dyn
analyzers are commonly used in Ethiopia including St’ Paul’s Hospital Millennium Medical
College. However, their performance has not been evaluated in most cases. If hematology
analyzers are not verified and evaluated for the specific population they serve the diagnosis of
many of diseases and hematology related clinical disorders will be unreliable.
Objective: To evaluate the performance specifications of Cell-Dyn 1800 and Sysmex KX-21
that are found in St. Paul’s Hospital Millennium Medical College.
Methods: A hospital based cross-sectional study with purposive sampling technique was used at
St. Paul’s Hospital Millennium Medical College from April 1 to April 8; 2015. A sample of
normal values was used for repeatability, high target values of hemoglobin, RBC, WBC and
platelets for linearity and carryover checks with subsequent background count were used. Data
were collected using observation checklist and then entry, cleaning and analysis were performed
by Microsoft Excel 2007 and SPSS version 20. Percentage, %CV, residual plotting, and
Pearson ́s correlation coefficient were used to describe the results.
Result: precision check revealed that both Sysmex KX-21 and Cell-Dyn 1800 values fall within
the manufacturers’ specifications. Linearity verifications of WBC, Hemoglobin, RBC and
Platelet showed that both analyzers produced a very good correlation coefficient of > 0.97, which
is also confirmed by residual plotting where all the values of the diluted samples surpassed the
manufacturers’ specifications. As to carryover both analyzers showed an excellent carryover
percentage of <1% which surpassed the manufacturers’ specifications.
Conclusion: Sysmex KX-21 and Cell-Dyn 1800 met the manufacturer’s specifications for
precision, linearity and carryover
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Keywords
Hematology Analyzers, Paul’s Hospital Millennium Medical