Prevalence of Hyperglycemia and Associated factors among People Living with HIV on Dolutegravir based Antiretroviral Therapy Regimen in Tikure Anbessa Specialized Hospital: A Hospital-based Cross-sectional Study
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Date
2021-12
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Publisher
Addis Abeba University
Abstract
Background
The introduction of dolutegravir based Antiretroviral Therapy (ART) regimen has provided
a potent treatment option for people living with HIV/AIDS. However, clinical settings
showed growing evidence that dolutegravir could result in significant hyperglycemia. The
prevalence of hyperglycemia in HIV patients taking dolutegravir is unknown. Knowledge
of dolutegravir associated hyperglycemia is important for early interventions to reduce
morbidity and mortality related to uncontrolled plasma glucose among HIV patients on
DTG containing ART drugs.
Objective
The objective of this study was to assess the prevalence of hyperglycemia among People
living with HIV taking dolutegravir based ART regimen and associated factors.
Methods
A cross-sectional study design was used. Study participants who met eligibility criteria
were continuously selected and recorded clinical and laboratory data. Fasting blood
glucose (FBS) was done using a point of care glucometer(prodigy™). Maximum data
quality was ensured, entered into epi info and analyzed with SPSS version 26 software.
The study was conducted from June 2021 to November 2021.
Results
The population studied were predominantly females (70%). The mean age was 46.2 years
(SD=10.2 years). The majority were in the age group 41-65 years (66.5%). Hyperglycemia
was observed in 38 (19%) of the study participants. Bivariable and multivariable logistic
regression showed no significant association of hyperglycemia with the independent
variables.
Conclusion
The study showed a consistent hyperglycemic risk for patients on dolutegravir and pointed
out the usefulness of a glucose monitoring plan for such patients. The study also
highlighted the importance of routine body weight monitoring in patients taking
dolutegravir.
Description
Keywords
Hyperglycemia, dolutegravir, prevalence, Tikure Anbessa specialized hospital ART clinic, Ethiopia.