Assessment of Renal function and Hematological Profile among Khat (Catha Edulis) Chewer and non Chewer Type 2 Diabetes Mellitus Patients Attending Harar Jugol Hospital, Eastern Ethiopia.
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Date
2021-02
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Addis Abeba University
Abstract
Back ground: Diabetes mellitus (DM) is a common endocrine disorder
characterized by the presence of chronic hyperglycemia and it’s the leading cause
of end stage renal disease (ESRD). In addition to DM some factors suspected to
be the cause of the renal problems are drug abuse. World Health Organization
(WHO) classified khat (Catha edulis) as a substance of abuse. Khat interferes
with normal body functions, which could lead to adverse health effects on organs
and systems of the body.
Objective: The aim of this study was to compare fasting blood sugar (FBS), renal
function and hematological profile among khat chewer and non chewer type 2
DM (T2DM) patients attending at Harar Jugol Hospital, Eastern Ethiopia.
Methodology: Comparative cross sectional study was conducted on a total of 100
T2DM patients that are divided into two groups (khat chewers and non chewers).
Socio demographic data were collected by using standardized questionnaire.
Blood sample collection was done through standardized techniques. Automated
COBAS 6000 and Sysmex KX-21N hematology analyzers were used to analyze
the samples. Statistical data analysis was held by SPSS version 25 model.
Result: Serum FBS and creatinine concentration showed statistically non
significant elevation among kaht chewers (p > 0.05). White blood cell (WBC),
Platelet (PLT) and hematocrit (HCT) of the khat chewers were significantly
higher than non chewers (p<0.05). On the other hand Mean Corpuscular
Hemoglobin Concentration (MCHC) and Mean Platelet Volume (MPV) of the
khat chewers were significantly lower than non chewers (p<0.05).
Conclusion: Chewing khat among T2DM patients might have an effect on FBS,
kidney function and hematological profile. Therefore further study is
recommended on the effect of khat chewing among DM patients.
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Keywords
Khat, Catha edulis, Diabetes mellitus, Renal function, Hematology