Assessment of Medication Related Problems and Contributing Factors among Ambulatory Patient with Chronic Kidney Disease at St. Paul’s Hospital Millennium Medical College, Addis Ababa, Ethiopia
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Date
2020-06
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Addis Abeba University
Abstract
Chronic kidney disease (CKD)is the reduction in the Glomerular Filtration Rate (GFR) and
urinary abnormalities or a structural abnormality of renal tract which is explained by pathologic
kidney abnormalities, persistent proteinuria, and other urine abnormalities on two occasions
separated by >90 days. As kidney function declines, number and complexity of medication
increase with the progression of the disease. Due to this Patients with this disease are at high risk
for medication-related problems because of their condition and the multiple medications required
for treatment of the causative disorders, and the complications associated with the disease. This
study aimed at establishing the extent of medication related problems among patients with chronic
kidney disease as well as exploring associations of different covariates with the problem identified.
Hospital based cross-sectional study was conducted among ambulatory patients with chronic
kidney disease at St. Paul’s Hospital Millennium Medical College, Addis Ababa, Ethiopia from 1
of June to 30
th
of August 2019. Patient with chronic kidney disease stage 1, 2, 3, and 4 adult
ambulatory patients were included in the study. A total of 325 medication related problems were
identified from 204 (82.3%) study participants giving 1.6 MRPs per participants. One medication
related problem was identified in 114 (55.9%) patients while two in 64 (31.4%). From the total
of identified problems most common class of MRP identified were need additional drug therapy
problems 114 (35.1%) followed by non-compliance 54 (16.6%). This study showed that only
occupation (AOR=5.2, 95% CI: 1.292-21.288, P=0.020) and Angiotensin converting enzyme
inhibitor (ACEI)use (AOR=6.6, 95% CI: 2.202-19.634, P=0.001)had association with the
occurrence of medication related problems. In general, our study suggest that medication related
problems experienced by each chronic kidney disease patients were high. In terms of types of
MRPs, this study showed that need additional drug therapy was frequently identified types.
st
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Keywords
Chronic Kidney Disease, Medication Related Problems.