Bacterial and Fungal Profile, Antibacterial Drug Susceptibility Pattern, and Associated Factors of Isolates Recovered from Kidney Transplant Recipients' Urine Samples at Saint Paul Hospital Millennium Medical College, Addis Ababa, Ethiopia.
| dc.contributor.advisor | Bitew Adane | |
| dc.contributor.author | Tesfaye Lemlem | |
| dc.date.accessioned | 2021-11-14T06:32:22Z | |
| dc.date.accessioned | 2023-11-06T08:56:58Z | |
| dc.date.available | 2021-11-14T06:32:22Z | |
| dc.date.available | 2023-11-06T08:56:58Z | |
| dc.date.issued | 2021-09 | |
| dc.description.abstract | Background: Urinary tract infections (UTIs) are the most infections in renal transplantrecipients and it has serious consequences in several countries including Ethiopia. Objective: To determine the bacterial and fungal profile, antibacterial drug susceptibilitypatterns and risk factors for urinary tract infections caused by bacteria and fungal etiologicalagents from urine of kidney transplanted patients at SPHMMC Addis Ababa, Ethiopia. Method: A hospital-based cross-sectional study was conducted from Novemb2021. A structured questionnaire was used to collect data on socio-demographic factors andclinical conditions. Blood, MacConkey, and brain heart infusion agar were used to culture allurine samples. Gram stain, biochemical tests, and chromagar for yeast were used to characterizeall culture positives were done according to the standard technique. All bacterial isolates weretested for antibiotic susceptibility using the Kirby-Bauer method. The possible risk factors wereassessed using simple and multivariate logistic regressions. Results: 63 pathogenic microorganisms were found in 207 clinical specimens. Gram negativebacteria accounted for 63.5 %, Gram positive bacteria for 23.8% and fungal isolates represented12.69 %. The most common bacteria identified in urinary tract infections (UTIs) were E. coli,Klebsiella pneumoniae, and Coagulase negative staphylococcus. Candidia krusei and Candidiaalbicans was among fungal isolates. Multidrug resistances were observed among 82% of Gramnegativebacteria. The highest rates of antimicrobial resistance were observed inAminoglycosides and 3rd generation cephalosporins. Carbapenem, Nitrofurantoin, Nalidixicacid, Amikacin and Fluoroquinolones were the most effective antibiotic to treat UTIs. Conclusion: Candidia albicans and Candidia krusie funguria were shown to be prevalent UTIsin people who had their kidneys transplanted, according to the study. Bacterial isolates showedresistance to commonly used antibiotics. These data are essential for identifying future potentialprevention strategies against UTI in kidney transplant recipients, as well as the causal agent,related factor and antibiotic resistance pattern. | en_US |
| dc.identifier.uri | http://etd.aau.edu.et/handle/123456789/28633 | |
| dc.language.iso | en_US | en_US |
| dc.publisher | Addis Abeba University | en_US |
| dc.subject | Urinary tract infection, Bacterial and fungal profile, Antibacterial susceptibility patterns, Risk factor Addis Ababa, Ethiopia. | en_US |
| dc.title | Bacterial and Fungal Profile, Antibacterial Drug Susceptibility Pattern, and Associated Factors of Isolates Recovered from Kidney Transplant Recipients' Urine Samples at Saint Paul Hospital Millennium Medical College, Addis Ababa, Ethiopia. | en_US |
| dc.type | Thesis | en_US |