Selected Hematological and biochemical profiles of burn patients visiting Yekatit 12 Hospital and AaBET Hospital, Addis Ababa,Ethiopia
| dc.contributor.advisor | Negash, Mikias (M.Sc., PhD candidate) | |
| dc.contributor.advisor | Hussein, Mintewab (B.Sc., M.Sc.) | |
| dc.contributor.author | Legese, Ashenafi | |
| dc.date.accessioned | 2021-11-16T07:38:44Z | |
| dc.date.accessioned | 2023-11-06T08:57:01Z | |
| dc.date.available | 2021-11-16T07:38:44Z | |
| dc.date.available | 2023-11-06T08:57:01Z | |
| dc.date.issued | 2021-07 | |
| dc.description.abstract | Background: Burn injuries are classified as one of the most devastating of all injuries and major global public health crisis. It is also one of the injuries which have pronounced effects on changing body biological parameters. However, little is known with regard to strategic management of burn patients by using an expected alteration of hematological and biochemical parameters in Ethiopia. Objectives: To determine selected Hematological and biochemical profile of burn patients at Yekatit 12 medical hospital and AaBET Hospital, Addis Ababa, Ethiopia from October, 2020 to July, 2021. Methods: A prospective cross-sectional study was conducted among 72 burn patients and 71 control groups from October, 2020 to July, 2021 at Yekatit 12 and AaBET medical hospitals, Addis Ababa, Ethiopia. Complete blood Count and biochemical assays were performed using Beckman coulter and Roche Diagnostic Cobas C311 automated analyzers respectively. Data was entered, analyzed and interpreted by using SPSS version 24. Association of selected Hematological and biochemical profile were done with the severity of burn. Statistical significance was defined as p value < 0.05 with 95% confidence interval. Results: Of the total 72 burn patients, 37(51.4%) were females and 32(44.4%) were children aged from 1 to 15 years old. Of the total 71 controls, males were 36(50.7%) and 39(54.9%) were adults >30 years old. Both burn patients and control groups resided in Urban areas 42(58.3% and 36(57.7%) respectively. Most injuries were Second degree burn 46(63.9%) caused mainly by Scald 31(43.1%) with 10-20% Total Body Surface Area (TBSA %) affected in the majority of cases (29(40.3%)). The majority of the Scald occurred in young children aged 1-15 years old 17(53.1%) Blood WBC count was initially raised and gradually decreased. HGB and HCT level was low during admission as compared to control group and increased on 1 st and 2 weeks. RBC count was elevated during admission comparing with control and then decreased. Serum creatinine and urea levels decreased on admission, 1 st and 3 rd nd weeks but showed increment on 2 week. Serum AST levels increased on admission and 3 rd week. But it decreased on 1 weeks. With regard to serum ALT levels, there was a significant increment (p<0.05) on admission day, non-significant (p>0.05) increment on 1 st week and 3 rd week and there was a decrease on 2 nd week. In case of serum Na + electrolyte concentration, there was decrement on admission and 1 st week and increased on 2 nd and 3 rd st weeks. With regard to serum K concentration, it decreased on admission and on 3 rd week, but there was an elevation on 1 and 2 nd weeks. Severity of burn high (TBSA %) had a direct relationship with WBC mean change but it was inversely related to platelet mean change. There was slightly high change of biochemical profile with high TBSA value. Conclusion: Various selected hematological and biochemical changes have been observed in burn patients. Thus this finding can be helpful to the health care team to make careful monitoring of these hematological and biochemical parameters which can help improve the health of burn patients, reduce mortality rate and improve survival. | en_US |
| dc.identifier.uri | http://etd.aau.edu.et/handle/123456789/28693 | |
| dc.language.iso | en_US | en_US |
| dc.publisher | Addis Abeba University | en_US |
| dc.subject | Hematological Parameters, Biochemical Parameters, Serum Electrolytes, Severe Burn. | en_US |
| dc.title | Selected Hematological and biochemical profiles of burn patients visiting Yekatit 12 Hospital and AaBET Hospital, Addis Ababa,Ethiopia | en_US |
| dc.type | Thesis | en_US |