Prevalence of Transfusion Transmissible Infections and Its Cost Analysis among Voluntary Blood Donors at Shashemane and Wolaita Sodo Blood Banks, Southern Ethiopia.
| dc.contributor.advisor | Sisay,Abay(MSc, PhD, Ass.Prof.) | |
| dc.contributor.advisor | Tamir,Zemenu(MSc, PhD, Ass. Prof.) | |
| dc.contributor.author | Asrat,Bilen | |
| dc.date.accessioned | 2026-06-22T16:00:21Z | |
| dc.date.available | 2026-06-22T16:00:21Z | |
| dc.date.issued | 2025-06 | |
| dc.description.abstract | Background: Blood transfusion is a vital healthcare intervention, but the risk of infections like Hepatitis B virus (HBV), Hepatitis C virus (HCV), Human Immunodeficiency Virus (HIV), and syphilis remains a major concern due to prolonged viremia and latent phases. Cost analysis, particularly the Activity-based costing model (ABC), aids in financial decision-making by linking costs to specific activities. Despite having these challenges, there is not well-documented evidence, particularly in the southern part of our country. Hence, this study aims to determine the prevalence of transfusion-transmissible infections among blood donors and its cost of analysis in Shashemane and Wolaita Blood Banks. Methods: A cross-sectional study was conducted from March to May 2024 at Shashemane and Wolaita Sodo Blood Banks, involving 568 consecutive blood donors. Data were collected using a semi-structured questionnaire by trained personnel. Transfusion-transmissible infections (TTIs) were tested using Chemiluminescent Microparticle Immunoassay. The cost of TTIs was analyzed using Activity-Based Costing (ABC) to trace individual infections, and costs were compared between sequential and simultaneous testing approaches. Result: From the total number of 568 blood units collected, 34 donors were positive for any of the TTI tested, giving an overall positivity rate of 6.0%. The sero-prevalence of Hepatitis B virus (HBV), Hepatitis C virus (HCV), Syphilis, and Human Immunodeficiency Virus (HIV) was 18(3.2%), 7(1.2%), 6(1.1%), 3(0.5%), respectively. In this study, by using the activity-based cost analysis method, the single cost of Hepatitis B virus, Hepatitis C virus, Syphilis, and Human Immunodeficiency Virus was 1.8926$, 2.9628$, 1.8231$, and 1.9631$. There was a difference in cost between the simultaneous versus newly sequential testing algorithms was $1,183.66. Conclusion: The prevalence of transfusion-transmitted infections (TTIs) was higher in this study area than in other regions of Ethiopia. The simultaneous testing strategy incurred higher costs than the sequential testing strategy. This suggests that the newly proposed testing method is a more cost-effective solution compared to the parallel or current testing method. | |
| dc.identifier.uri | https://etd.aau.edu.et/handle/123456789/8508 | |
| dc.language.iso | en_US | |
| dc.publisher | Addis Ababa University | |
| dc.subject | Sero prevalence | |
| dc.subject | Cost analysis | |
| dc.subject | transfusion-transmissible infections | |
| dc.subject | voluntary blood donors | |
| dc.subject | Shashemane and Wolaita Sodo blood banks | |
| dc.title | Prevalence of Transfusion Transmissible Infections and Its Cost Analysis among Voluntary Blood Donors at Shashemane and Wolaita Sodo Blood Banks, Southern Ethiopia. | |
| dc.type | Thesis |