Effect of Isoniazid (INH) Prophylaxis on Blood Level of Tacrolimus, Liver Function Test and Renal Function Test Used for Kidney Recipient Patient Attending St. Paul’s Hospital Millennium Medical College, Addis Ababa, Ethiopia.
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Date
2020-02
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Addis Abeba University
Abstract
Background: Tacrolimus is a common immunosuppressant, approved for the prophylaxis oforgan rejection in renal transplantation .On the other hand INH is a drug used as an antibacterialor prophylaxes for those kidney recipients. In Ethiopia, those individuals who underwent kidneytransplantation took both INH and Tacrolimus drugs. Nevertheless the effect of INH on theefficacy of Tacrolimus drugs was not well known in Ethiopia.
Objective: To evaluate the effect of INH on blood level of tacrolimus drug among kidneyrecipient individuals attending St. Paul Hospital, kidney center.
Methods: An institutional based cross-sectional study was conducted on 14 kidney recipientpatients from January to September 2019. The study participants received both tacrolimus drugsas an immunosuppressant and INH as a prophylaxis. Clinical and laboratory data including drugfunctional tests were recorded at the time of treatment with INH and completion of this treatmentafter a week, biochemical analysis was also done.
Result: The concentration of Tacrolimus drug level with INH prophylaxis was significantlyhigher when compared to the concentration after finishing INH prophylaxis; p=0.002. Besides,the liver function parameters were significantly increased when tacrolimus was taken with INH;AST; P=0.001, ALP; P=0.001, ALT; P=0.01. Similar effect of renal function test values on thosepatients taking tacrolimus with and without INH was seen; as Creatine; p=0.001, Urea; p=0.003was significantly higher when compared to the values after INH prophylaxis was finished. Therewere no statistically significance difference observed in Total bilirubin; p=0.933 and Directbilirubin; p=0.710 during and post treatment values.
Conclusion: Kidney recipient patients who used INH prophylaxis showed alteration of LFT,RFT and blood concentration of tacrolimus (BCT).Biochemical tests except bilirubin weresignificantly affected by INH drug.
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Keywords
Isoniazid drug, Tacrolimus drug, Kidney Transplant