Effect of Isoniazid (INH) Prophylaxis on Blood Level of Tacrolimus, Liver Function Test and Renal Function test used for Kidney recipient Patient attending St. Paul’s Hospital Millennium Medical College, Addis Ababa, Ethiopia.
No Thumbnail Available
Date
2020-02
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Addis Abeba University
Abstract
Background: Tacrolimus is a common immunosuppressant, approved for the prophylaxis of
organ rejection in renal transplantation .On the other hand INH is a drug used as an antibacterial
or prophylaxes for those kidney recipients. In Ethiopia, those individuals who underwent kidney
transplantation took both INH and Tacrolimus drugs. Nevertheless the effect of INH on the
efficacy of Tacrolimus drugs was not well known in Ethiopia.
Objective: To evaluate the effect of INH on blood level of tacrolimus drug among kidney
recipient individuals attending St. Paul Hospital, kidney center.
Methods: An institutional based cross-sectional study was conducted on 14 kidney recipient
patients from January to September 2019. The study participants received both tacrolimus drugs
as an immunosuppressant and INH as a prophylaxis. Clinical and laboratory data including drug
functional tests were recorded at the time of treatment with INH and completion of this treatment
after a week, biochemical analysis was also done.
Result: The concentration of Tacrolimus drug level with INH prophylaxis was significantly
higher when compared to the concentration after finishing INH prophylaxis; p=0.002. Besides,
the liver function parameters were significantly increased when tacrolimus was taken with INH;
AST; P=0.001, ALP; P=0.001, ALT; P=0.01. Similar effect of renal function test values on those
patients taking tacrolimus with and without INH was seen; as Creatine; p=0.001, Urea; p=0.003
was significantly higher when compared to the values after INH prophylaxis was finished. There
were no statistically significance difference observed in Total bilirubin; p=0.933 and Direct
bilirubin; p=0.710 during and post treatment values.
Conclusion: Kidney recipient patients who used INH prophylaxis showed alteration of LFT,
RFT and blood concentration of tacrolimus (BCT). Biochemical tests except bilirubin were
significantly affected by INH drug.
Description
Keywords
Isoniazid drug, Tacrolimus drug, Kidney Transplant