Effect of Isoniazid (INH) Prophylaxis on Blood Level of Tacrolimus, Liver Function Test and Renal Function test used for Kidney recipient Patient attending St. Paul’s Hospital Millennium Medical College, Addis Ababa, Ethiopia.

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Date

2020-02

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Addis Abeba University

Abstract

Background: Tacrolimus is a common immunosuppressant, approved for the prophylaxis of organ rejection in renal transplantation .On the other hand INH is a drug used as an antibacterial or prophylaxes for those kidney recipients. In Ethiopia, those individuals who underwent kidney transplantation took both INH and Tacrolimus drugs. Nevertheless the effect of INH on the efficacy of Tacrolimus drugs was not well known in Ethiopia. Objective: To evaluate the effect of INH on blood level of tacrolimus drug among kidney recipient individuals attending St. Paul Hospital, kidney center. Methods: An institutional based cross-sectional study was conducted on 14 kidney recipient patients from January to September 2019. The study participants received both tacrolimus drugs as an immunosuppressant and INH as a prophylaxis. Clinical and laboratory data including drug functional tests were recorded at the time of treatment with INH and completion of this treatment after a week, biochemical analysis was also done. Result: The concentration of Tacrolimus drug level with INH prophylaxis was significantly higher when compared to the concentration after finishing INH prophylaxis; p=0.002. Besides, the liver function parameters were significantly increased when tacrolimus was taken with INH; AST; P=0.001, ALP; P=0.001, ALT; P=0.01. Similar effect of renal function test values on those patients taking tacrolimus with and without INH was seen; as Creatine; p=0.001, Urea; p=0.003 was significantly higher when compared to the values after INH prophylaxis was finished. There were no statistically significance difference observed in Total bilirubin; p=0.933 and Direct bilirubin; p=0.710 during and post treatment values. Conclusion: Kidney recipient patients who used INH prophylaxis showed alteration of LFT, RFT and blood concentration of tacrolimus (BCT). Biochemical tests except bilirubin were significantly affected by INH drug.

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Keywords

Isoniazid drug, Tacrolimus drug, Kidney Transplant

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