Assessment of Prophylactic Administration of Propofol on Incidence and Severity of Emergence agitation in Pediatrics ENTand Ophthalmic Surgery at Saint Paul Hospital Millenium Medical College. Addis Abeba, Ethiopia ,November 2018-May2019G.C.Cohort Study.
No Thumbnail Available
Date
2019-05
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Addis Ababa University
Abstract
Introduction: Emergence agitation is a common problem that can occur after administration
of general anesthesia and during recovery time especially in pediatric patients, which can
result in life threatening events if not managed adequately and timely. The use of modern
inhalational anesthetic agents like sevoflurane, isoflurane and also halothane is also another
cause for emergence agitation. Currently use of propofol is gaining acceptance largely on
decreasing emergence agitation and also post-operative nausea and vomiting. As smooth
recovery is mandatory for the well-being of patients addressing such issues will be valuable.
Objective: The objective of this study is to assess the effect of prophylactic administration of
Propofol on incidence and severity of emergence agitation in pediatrics ENT and Ophthalmic
surgery at saint Paul hospital Millennium medical college. Addis Ababa.
Method: An institutional based prospective cohort study design was conducted at Saint Paul
hospital millennium medical college located Addis Ababa, Ethiopia from November 2018 to
May 2019. Elective ASA one and two, age 2-12 years old ninty pediatric patients who
Underwent General anesthesia for ENT and ophthalmic surgery were studied. Data were
collected from selected study Participants using anesthesia record sheet and observed
throughout their recovery room stay. By using systematic random sampling method, the
study participants allocated into two groups. Group P (n=45), who took propofol 1mg/kg at
the end of surgery and group NP (n=45), who did not take propofol at the end. SPSS version
20.0 was used for data entry and analysis. Comparison of variables between study groups
were done using Man Whitney u test, after normality is tested by shapiro wilk test.
Categorical variables statistical difference between groups were tested using chi square.
Significance was determined at p value <0.05. the result is presented by texts, tables and
graphs.
Result: post-operative emergence agitation occurred in 64% of patients in non-prophylactic
group and 31% in prophylactic group with a p value of 0.02. prophylactic group had lower
severity of post-operative emergence agitation at all times. At 5minute,15 minute and 30
minutes with a p value of 0.009 ,0.013 and 0.011 respectively.
Conclusion: we conclude that administering propofol 1mg/kg at the end of surgical
procedure in children undergoing general anesthesia for ENT and ophthalmic surgery is
important for reducing emergence agitation and severity for providing smooth recovery
postoperatively.
Recommendation: we recommend the use of 1mg/kg iv propofol at the end of surgical
Procedure for reducing post-operative emergence agitation and severity in pediatric patients
undergoing general anesthesia for ENT and ophthalmic surgery.
Description
Keywords
Prophylactic Administration ,Pediatrics ENT and Ophthalmic Surgery