Assessment of Prophylactic Administration of Propofol on Incidence and Severity of Emergence agitation in Pediatrics ENTand Ophthalmic Surgery at Saint Paul Hospital Millenium Medical College. Addis Abeba, Ethiopia ,November 2018-May2019G.C.Cohort Study.

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Date

2019-05

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Addis Ababa University

Abstract

Introduction: Emergence agitation is a common problem that can occur after administration of general anesthesia and during recovery time especially in pediatric patients, which can result in life threatening events if not managed adequately and timely. The use of modern inhalational anesthetic agents like sevoflurane, isoflurane and also halothane is also another cause for emergence agitation. Currently use of propofol is gaining acceptance largely on decreasing emergence agitation and also post-operative nausea and vomiting. As smooth recovery is mandatory for the well-being of patients addressing such issues will be valuable. Objective: The objective of this study is to assess the effect of prophylactic administration of Propofol on incidence and severity of emergence agitation in pediatrics ENT and Ophthalmic surgery at saint Paul hospital Millennium medical college. Addis Ababa. Method: An institutional based prospective cohort study design was conducted at Saint Paul hospital millennium medical college located Addis Ababa, Ethiopia from November 2018 to May 2019. Elective ASA one and two, age 2-12 years old ninty pediatric patients who Underwent General anesthesia for ENT and ophthalmic surgery were studied. Data were collected from selected study Participants using anesthesia record sheet and observed throughout their recovery room stay. By using systematic random sampling method, the study participants allocated into two groups. Group P (n=45), who took propofol 1mg/kg at the end of surgery and group NP (n=45), who did not take propofol at the end. SPSS version 20.0 was used for data entry and analysis. Comparison of variables between study groups were done using Man Whitney u test, after normality is tested by shapiro wilk test. Categorical variables statistical difference between groups were tested using chi square. Significance was determined at p value <0.05. the result is presented by texts, tables and graphs. Result: post-operative emergence agitation occurred in 64% of patients in non-prophylactic group and 31% in prophylactic group with a p value of 0.02. prophylactic group had lower severity of post-operative emergence agitation at all times. At 5minute,15 minute and 30 minutes with a p value of 0.009 ,0.013 and 0.011 respectively. Conclusion: we conclude that administering propofol 1mg/kg at the end of surgical procedure in children undergoing general anesthesia for ENT and ophthalmic surgery is important for reducing emergence agitation and severity for providing smooth recovery postoperatively. Recommendation: we recommend the use of 1mg/kg iv propofol at the end of surgical Procedure for reducing post-operative emergence agitation and severity in pediatric patients undergoing general anesthesia for ENT and ophthalmic surgery.

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Keywords

Prophylactic Administration ,Pediatrics ENT and Ophthalmic Surgery

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