Risk factors for fatigue among cancer patients attending cancer center of Tikure Anbessa Specialized Hospital in Addis Ababa, Ethiopia, 2023: unmatched case-control study
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Date
2023-06
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Addis Ababa University
Abstract
Background:Even though cancer-related fatigue (CRF) is a highly prevalent and distressing
symptom, its risk factors are mostly under assessed and reliable information on the causes of
fatigue in the Ethiopian population is scarce and needs further investigation
Objective: To investigate the possible risk factors for fatigue among cancer patients
attending the Tikure Anbessa Specialized Hospital in Addis Ababa, Ethiopia.
Material and Methods: From January 2023 to May 2023, an institution-based, unmatched
case-control study was conducted at Tikure Anbessa Specialised Hospital (TASH) in Addis
Abeba, Ethiopia, on 110 cases (cancer patients who received chemotherapy) and 220 controls
(cancer patients who did not receive chemotherapy). Face-to-face interviews with potential
study participants were used to choose them using a systematic random sampling technique.
The fatigue evaluation scale was used to measure exhaustion. In order to fit a binary logistic
regression (bi-variable and multi-variable) model, SPSS version 26 software was utilised.
The strength and direction of the link were determined using an adjusted odds ratio with
respect to the 95% confidence interval, and statistical significance was proclaimed at a p-
value of <0.05.
Results: This study found that the prevalence of fatigue were 77.2% cases,22.8%
controls,95% CI: (73.1–81.1%)
The mean ± standard deviation (SD) of the ages of the participants was 45.6±14.4 years,
(74 =63.3%)cases and (96 = 43.6%) controls had a history of repeated admission, 51
(46.4%)cases and 88 (40%) controls with stage three cancer, alcohol consumption 81
(73.6%), 15 (13.6%), and 14 (12.7%) of the case 162 (73.6%), 37 (16.8%), and 21 (9.5%)
of the controls, having depression (AOR: 2.83 (1.57, 5.10), chemotherapy use (AOR: 3.61
(2.10, 4.61),
In contrast to this ,not having a history of anemia (0.68 (0.40, 1.14)),and anxiety(AOR: 0.24
(0.14, 0.40)).
Conclusions and Recommendation:In this study, having depression and chemotherapeutic
use increased the odds of sustaining fatigue symptoms.
incontrast,not having anemia and anxiety reduced the odds of developing fatigue. Therefore,
cancer patients with chemotherapy usersand those who had depression. Nurse shall consider
fatigue as one of the vital sign in cancer patients and incorporate in vital sign sheet format.
Furthermore, education programs on fatigue, etiology and treatment shall be given for the
patients recommend that the focus of any action be on each of the identified relevant factors
in order to reduce the burden of fatigue.
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Keywords
Cancer-related fatigue, risk factors forfatigue, OncologyCenter, Ethiopia.