Histological and Functional Effect of Fluoride on Cerebral Cortex of the Brain
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Date
2014-07
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Addis Abeba University
Abstract
Fluoride is omnipresent in our environment and has been added to drinking water supplies
with a recommended dose. Drinks, tooth pastes, mouth rinses, dietary supplements and foods
are also considered as sources of fluorides. This paper reviews the scientific literatures linking
fluoride with its effect on histology and function of cerebral cortex of the brain. In this paper
the role of fluoride in region specific and sub-cellular distribution of the brain with the
relation of its neurotoxicity is highlighted. Studies were assessed by focusing on the dose of
fluoride, duration of exposure, type of experimental animals used to measure the effect of
fluoride. The literatures reviewed in the present paper used mice, rats and rat offspring as
experimental animals. From the literatures reviewed in the present paper, fluoride showed to
be neurotoxic chemical which affects the biochemical content of brain, cause weight loss,
cause neurodegeneration, histological alternation in hippocampus and cerebral cortex of the
brain, disrupting behavioral activities and cause reduction in cognitive and memory functions.
Keywords: Cerebral cortex, Histopathological effect, Weight loss, Biochemical change,
Neurobehavioral toxicity and Fluoride
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Keywords
Cerebral Cortex, Histopathological effect, Weight loss, Biochemical Change, Neurobehavioral Toxicity and Fluoride