Assessments of Liver Function, Plasma Protein level and HS CRP in Breast Cancer Patients on Doxorubicin (Adriamycin) and Cyclophosphamide (Cytoxan) (AC) Chemotherapy Attending Tikur Anbessa Specialized Hospital (TASH), Ethiopia
| dc.contributor.advisor | Adissu, Sisay (PhD) | |
| dc.contributor.advisor | Tigeneh, Wondemagegnehu(MD) | |
| dc.contributor.author | Nida, Tamrat | |
| dc.date.accessioned | 2021-06-18T08:13:23Z | |
| dc.date.accessioned | 2023-11-29T04:18:25Z | |
| dc.date.available | 2021-06-18T08:13:23Z | |
| dc.date.available | 2023-11-29T04:18:25Z | |
| dc.date.issued | 2021-06 | |
| dc.description.abstract | Introduction : Breast cancer is the commonest malignancy of females. It is the leading cause of cancer death in developing countries including Ethiopia. Chemotherapy with Adriamycin & Cytoxan (AC) is one of the main treatment options used for breast cancer. The drugs are entirely metabolized in the liver and may influence liver function.This study is intended to assess the influence of these drugs on liver function, serum protein level, and hs CRP. Objective: The study aimed to assess the influence of chemotherapy (AC) on liver function, through determination of liver enzymes, total serum protein, serum albumin and and hs CRP between AC treated and untreated breast cancer patients at the TASH oncology unit from January 2020 to November 2020. Patients and methods: A comparative cross-sectional study design was used to determine liver enzymes (AST, ALT, ALP) , total plasma protein, albumin and serum hsCRP level between AC chemotherapy untreated and treated breast cancer patients. A total of 82 female breast cancer study subjects were enrolled in this study and among which 39 of them were AC untreated and 43 of them were after taking 4 th cycle of AC chemotherapy. Result: Mean comparison of serum liver function enzymes, hs CRP, albumin, and total protein levels among AC untreated and treated breast cancer patients showed that there was no significant difference between them. Higher levels of ALP were observed among AC chemotheraphy untreated old age group 50-90 yrs patients than the AC treated group. However no significant differences in the other biochemical parameters among the two groups at this age. Conclusion: The current study didn’t reveal any significant differences in the levels of liver fuction enzymes, total protein, albumin and hsCRP level between AC treated and untreated groups. Cause a significant change in a biochemical marker of bone turnover (ALP) among old age breast cancer patients. | en_US |
| dc.identifier.uri | http://etd.aau.edu.et/handle/123456789/26915 | |
| dc.language.iso | en_US | en_US |
| dc.publisher | Addis Abeba University | en_US |
| dc.subject | Breast Cancer Patients,Doxorubicin,Cyclophosphamide,Chemotherapy | en_US |
| dc.title | Assessments of Liver Function, Plasma Protein level and HS CRP in Breast Cancer Patients on Doxorubicin (Adriamycin) and Cyclophosphamide (Cytoxan) (AC) Chemotherapy Attending Tikur Anbessa Specialized Hospital (TASH), Ethiopia | en_US |
| dc.type | Thesis | en_US |