Assessments of Liver Function, Plasma Protein level and HS CRP in Breast Cancer Patients on Doxorubicin (Adriamycin) and Cyclophosphamide (Cytoxan) (AC) Chemotherapy Attending Tikur Anbessa Specialized Hospital (TASH), Ethiopia
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Date
2021-06
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Addis Abeba University
Abstract
Introduction
:
Breast cancer is the commonest malignancy of females. It is the leading cause of
cancer death in developing countries including Ethiopia. Chemotherapy with Adriamycin &
Cytoxan (AC) is one of the main treatment options used for breast cancer. The drugs are entirely
metabolized in the liver and may influence liver function.This study is intended to assess the
influence of these drugs on liver function, serum protein level, and hs CRP.
Objective: The study aimed to assess the influence of chemotherapy (AC) on liver function,
through determination of liver enzymes, total serum protein, serum albumin and and hs CRP
between AC treated and untreated breast cancer patients at the TASH oncology unit from
January 2020 to November 2020.
Patients and methods: A comparative cross-sectional study design was used to determine liver
enzymes (AST, ALT, ALP) , total plasma protein, albumin and serum hsCRP level between AC
chemotherapy untreated and treated breast cancer patients. A total of 82 female breast cancer
study subjects were enrolled in this study and among which 39 of them were AC untreated and
43 of them were after taking 4
th
cycle of AC chemotherapy.
Result: Mean comparison of serum liver function enzymes, hs CRP, albumin, and total protein
levels among AC untreated and treated breast cancer patients showed that there was no
significant difference between them. Higher levels of ALP were observed among AC
chemotheraphy untreated old age group 50-90 yrs patients than the AC treated group. However
no significant differences in the other biochemical parameters among the two groups at this age.
Conclusion: The current study didn’t reveal any significant differences in the levels of liver
fuction enzymes, total protein, albumin and hsCRP level between AC treated and untreated
groups. Cause a significant change in a biochemical marker of bone turnover (ALP) among old
age breast cancer patients.
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Keywords
Breast Cancer Patients,Doxorubicin,Cyclophosphamide,Chemotherapy