Prevalence and Risk Factors of Retinopathy of Prematurity among Infants in Minilik II Hospital: a Retrospective Study, Addis Ababa, Ethiopia, 2020.
| dc.contributor.advisor | Tsige Yosief | |
| dc.contributor.author | Endale Hana | |
| dc.date.accessioned | 2020-12-06T06:25:14Z | |
| dc.date.accessioned | 2023-11-06T09:01:59Z | |
| dc.date.available | 2020-12-06T06:25:14Z | |
| dc.date.available | 2023-11-06T09:01:59Z | |
| dc.date.issued | 2020-06 | |
| dc.description.abstract | Introduction: Retinopathy of prematurity is the growth of abnormal retinal vessels secondary todeficient vascularization of the retinal tissue as a result of hyperoxia causing reduces a regulationof vascular endothelial growth factor and death of endothelial cells. In developing countries,heavier and term infant develop ROP since there is inadequate awareness of the risk factors ofthe disease development. There are many risk factors of ROP; the major risk factors are low birthweight (BW), small gestational age (GA), and long term oxygen therapy. Objective: To assess the prevalence and risk factors of retinopathy of prematurity among infantsin Minilik II Hospital, Addis Ababa, Ethiopia, 2020. Methodology: An institutional based retrospective cross sectional study was conducted fromMarch to April 2020 at Minilik II hospital pediatrics outpatient referral eye clinic. A sample size(301) was determined by using single population proportion formula. And study subjects wereselected using systematic random sampling method. Data was collected from medical records ofall infants from January 2018 - December 2019 with a structured check list. The collected datawas entered and cleaned using Epi data 6.4.2.0 and then exported & analyzed using SPSSversion 25. Bivariate and multivariate analysis was used to recognize the associated factors. Result: Out of 301 infants enrolled in the study, 39(13%) developed ROP. Of these more thanhalf (56.4%) of them who had ROP were on Zone II + Stage 1 followed by Zone II + stage 5(12.8%) and Stage 5(10.2%). From those infants who had ROP, 16(41%) infants were regressedspontaneously with follow up. Univariate analysis showed that gestational age, birth weight,oxygen therapy, preeclampsia, apnea, RDS, anemia, blood transfusion and sepsis were asignificant variable. But, birth weight, oxygen therapy and sepsis remained a significant factor inmultivariate analysis. Conclusion and recommendation: The prevalence of ROP in this study was 13%. Birth weight,oxygen therapy and sepsis were a significant factor for the development of ROP. Preventing riskfactors of ROP that are underweight at birth, sepsis and long term oxygen therapy are veryimportant to reduce childhood blindness. | en_US |
| dc.identifier.uri | http://etd.aau.edu.et/handle/123456789/23864 | |
| dc.language.iso | en_US | en_US |
| dc.publisher | Addis Abeba University | en_US |
| dc.subject | Retinopathy of prematurity, Retina, Premature | en_US |
| dc.title | Prevalence and Risk Factors of Retinopathy of Prematurity among Infants in Minilik II Hospital: a Retrospective Study, Addis Ababa, Ethiopia, 2020. | en_US |
| dc.type | Thesis | en_US |