Determination of community-based reference intervals for selected clinical chemistry parameters among apparently healthy adult individuals in Mekelle city, Tigrai, Northern Ethiopia from December 2018 to May 2019: a cross sectional study.
| dc.contributor.advisor | Wolde, Mistire (MSc, Ph.D., Associate Professor) | |
| dc.contributor.advisor | Tsegaye, Aster(MSc, Ph.D., Associate Professor) | |
| dc.contributor.author | Gebremariam, Gebreslassie | |
| dc.date.accessioned | 2020-05-21T13:57:59Z | |
| dc.date.accessioned | 2023-11-06T08:56:33Z | |
| dc.date.available | 2020-05-21T13:57:59Z | |
| dc.date.available | 2023-11-06T08:56:33Z | |
| dc.date.issued | 2019-06 | |
| dc.description.abstract | Background: Reference Intervals (RIs) are important tools to differentiate health and disease individuals. Establishment of RIs specific for a given area is highly recommended, since RI vary from place to place based on genetics, lifestyle, environmental and nutritional factors. Although few studies have been conducted in Ethiopia to determine RI for clinical chemistry in the Amhara region and Gilgel gibe, they are limited to the specific population and there is no such study conducted in Tigrai. Therefore; this study aimed to determine RIs for selected clinical chemistry parameters among apparently healthy adult individuals in Mekelle city, Tigrai, Northern Ethiopia. Objective: To determine community-based reference intervals for selected clinical chemistry parameters among apparently healthy adult individuals in Mekelle city, Tigrai, Northern Ethiopia from December 2018 to May 2019. Method: A cross-sectional study was conducted to establish RI for selected clinical chemistry test among apparently healthy adult individuals in Mekelle city, Tigrai, Northern Ethiopia from December 2018 to May 2019. A total of 344 apparently healthy Study participants were selected based on structured questionnaire, physical examinations, parasitological, and urinalysis. SPSS version 23 was used to analyze the data. RI was determined using 2.5 th and 97.5 percentiles and P value < 0.05 was considered as statistically significant. Result: A RI was established for ten clinical chemistry tests. Among them, three parameters had no sex difference [total protein (5.9-8.25 g/dl), albumin (4.3-5.5 g/dl) and fasting blood sugar (73.7-115mg/dl)]; whereas the other seven had a statistically significant between the sexes: alkaline phosphatase (U/L) [49.3-152 and 58.3-178.6], alanine aminotransferase (U/L) [4.2-23.6 and 5.2-33], aspartate aminotransferase, (U/L) [12.3-34.1 and 15.2-36.74], bilirubin direct (mg/dl) [0.0114-0.553 and 0.019-0.606], bilirubin total (mg/dl) [0.075-0.84 and 0.15-1.08], Urea (mg/dl) [8.05-22.85 and 8.7-26.075], and creatinine (mg/dl) [0.46-0.96 and 0.42-1.153] for female and male respectively. Conclusion: There was a significant difference for ALP, ALT, AST, BilD, BilT, Urea and creatinine between sexes. This finding is important to improve the health system by providing accurate RI. th | en_US |
| dc.identifier.uri | http://etd.aau.edu.et/handle/123456789/21275 | |
| dc.language.iso | en_US | en_US |
| dc.publisher | Addis Abeba University | en_US |
| dc.subject | Clinical chemistry tests, Clinical tests, Ethiopia, Reference interval, and Reference value | en_US |
| dc.title | Determination of community-based reference intervals for selected clinical chemistry parameters among apparently healthy adult individuals in Mekelle city, Tigrai, Northern Ethiopia from December 2018 to May 2019: a cross sectional study. | en_US |
| dc.type | Thesis | en_US |