Association between ABO blood groups and postoperative pain in children after Adenotonsillectomy
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Date
2024-06
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Addis Ababa University
Abstract
Introduction: The main cause of morbidity after an adenotonsillectomy is generally recognized
to be pain. Clinically, there can be significant differences in pain perception and intensity
amongst people in the same surgical context, with similar pain states, similar pathologies, or with
similar disease severity. The Inter- individual difference for pain is influenced by genetic and
environmental factors. The diversity in individual differences in pain is partially explained by
minor alterations in DNA Among all DNA polymorphisms, the ABO blood type is one of the
most significant genetic phenotypes. Hence, Knowing about the relationship between ABO
blood system and post-operative pain can improve post-operative pain management and reduce
pain related sequela.
Objective: To investigate the association between ABO blood group and post-operative pain in
children after adenotonsillectomy in public hospitals of Addis Ababa, Ethiopia from February
2024 to April 2024.
Method: A multi-center prospective cohort study was conducted in public hospitals of Addis
Ababa among pediatrics patients who underwent adenotonsillectomy procedures under general
anesthesia with a total of 88 patients having four group based on blood type and each containing
22 patients. FLACC pain scale and post-operative analgesic consumption was recorded
postoperatively along with collection of demographic data. The measured outcomes were
postoperative pain indicated by the pain score and the total analgesic consumption among the
four major ABO blood groups. The participants in the study were selected by systematic random
sampling technique from each group. Data was collected by preoperative chart review,
intraoperative and postoperative observation. The data was entered into SPSS version 26 and
analysis of variable was undertaken by using one-way ANOVA, Kruskal Wallis H- rank test, and
chi-square test.
Result: FLACC pain scores were significantly higher in the AB and B blood groups' than those
of the A and O blood groups (P<0.05). Additionally FLACC pain scores of AB blood were the
highest among all (P<0.01). regarding to analgesia consumption children in the blood groups A
and O received much lower total dosages of analgesics during a 24-hour period than did children
in the AB and B blood groups (P<0.05).
Conclusion: In conclusion, the present study found that there is an association between blood
group and post-operative pain scores and post-operative analgesia consumption in children
undergoing adenotonsillectomy. We recommend clinicians to consider patients’ blood group
during pain management.
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Keywords
ABO blood group, FLACC pain score, Postoperative pain