Prevalence and Outcome of Health- Care Associated Infection in Neonates Admitted to Neonatal Intensive Care Unit Tikur Anbessa Specialized Hospital, Addis Ababa Ethiopia.
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Date
2023-11
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Addis Ababa University
Abstract
Background: Health care–associated infections are infections acquired in the hospital while
receiving treatment for other conditions. Healthcare-associated infection (HAI) is a serious
problem in neonates who are admitted to the neonatal intensive care unit (NICU) because of
impaired host-defense mechanisms, limited amounts of protective endogenous flora on skin and
mucosal surfaces at time of birth, reduced barrier function of their skin, use of invasive
procedures and devices, and frequent exposure to broad spectrum antibiotic agents. Due to
variations in definitions and reporting, the exact global burden of HAI cannot be accurately
estimated. There exists wide variation in the bacteriological profile and antibiogram of
microorganisms in different NICUs which changes consistently with time.
Objective: To assess the prevalence and outcome of HAI in neonates.
Study Setting: The study will be conducted in NICU of Tikur Anbessa Specialized Hospital,
Addis Ababa from December 2023 to January 2023.
Method: A hospital based retrospective cross-sectional study will be conducted on prevalence
and outcome of HAI in neonates. A data collection sheet will be designed to include baseline and
progress data for each admitted neonate who develops HAI. Data collection protocol will be
prepared, and data collectors will be trained as per the protocol. After data cleaning and entry,
analysis will be done using the Statistical Package for Social Sciences (SPSS). Descriptive and
analytical statistics will be used as applicable. Statistically significant association will be taken
for p values of <0.05.
Work Plan and Budget: This study will be conducted from December 2023 to January 2024.
This period will be utilized to finalize the research proposal, collect, and analyze the data. A total
of 40,000 birr will be used to cover the costs for data collection and supplies
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Keywords
Health care, Neonates, Neonatal Intensive Care Unit