Patterns of Anticoaulation and Outcome in COVID -19 Patients Admitted to TASH Isolation center, Addis Ababa Ethiopia, Retrospective Study (June 2020-June 2021)
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Date
2021-12
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Addis Ababa University
Abstract
Background
Earlier reports of high prevalence of thrombosis and related mortality has led to use of
anticoagulants being part of the main treatment with varying results. Despite current
large scale data showing credible benefits there are no studies done to determine the
pattern of anticoagulation use and outcome in COVID patients in Ethiopia.
OBJECTIVE
To assess patterns of anticoagulation and outcome, of COVID-19 patients admitted to
TASH isolation ward June2020- June 2021.
METHODOLOGY
Facility based retrospective cross-sectional study using secondary data analysis, was
conducted. Records were retrieved using TASH, isolation log book. 126 patients were
included. Data was analyzed using descriptive and binary logistic regression analysis
Result
Of the total 126 cases, Anticoagulation was used in 94 pts 74.6%. Therapeutic dose
anticoagulation was used in 13(13.8%) pts of which 8 had severe disease. Prophylactic
dose 79(84%), intermediate dose in two pts. UFH was used in 78(82.9%), LMWH
13(13.8%), DOAC 2(2.2%). only 58.8% of the patients received the full dose of
prescribed anticoagulation. Pulmonary Thrombo-Embolism occurred in 9 pts of which 8
had severe disease and nearly half were on anticoagulation. Venous thrombosis
occurred in 7 pts among those 5 had severe disease. Three out of the seven pts were
on anticoagulation. In Hospital mortality was (n=14, 11.8%).
Conclusion
In conclusion, majority of patients received anticoagulation with UFH in prophylactic
dosage. Anticoagulation use was not associated with diseases severity, in hospital
mortality or 3 months outcome. Complications of anticoagulation were rare and minor.
Complications were not associated with poor outcome.
Description
Keywords
COVID -19, Patients