Magnitude of Hyponatremia and its Associated Factors Among Acute Stroke Patients Admitted in Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia
| dc.contributor.advisor | . Amanuel Amare | |
| dc.contributor.advisor | Fikru Tsehayneh | |
| dc.contributor.advisor | Selam Kifelew | |
| dc.contributor.author | Wubsew Shimelis | |
| dc.date.accessioned | 2026-02-17T08:54:34Z | |
| dc.date.available | 2026-02-17T08:54:34Z | |
| dc.date.issued | 2025-02-11 | |
| dc.description.abstract | BACKGROUND: Stroke is a serious life-threatening medical condition which is responsible for more than six million deaths annually. It has become the second-leading cause of death and the third-leading cause of combined death and disability worldwide. In Ethiopia as well it is now regarded as a public health threat & remains an important cause of temporary & permanent disability. Significant determinants of poor outcome and mortality in stroke patients is related to both medical and neurological complications. Hyponatremia in stroke is frequently faced electrolyte disturbance. It is observed either on admission or during their hospitalization and associated with increased morbidity and mortality. OBJECTIVE: The end goal of this study is to measure magnitude of hyponatremia and its factors associated with it in acute stroke patients admitted in TASH. It also address associated conditions as contributory of hyponatremia. Magnitude of hypokalemia will be studied along with it as it is measure simultaneously in our laboratories. METHODOLOGY: A prospective observational cross-sectional study design was employed. Eligible men & women age 13 years and above who are willing and able to hand informed consent was participate in this study. Patients with transient ischemic attack (TIA), NIHSS < 5 were excluded from the study. Validated tools like NIHSS, GCS, ICH score and mRS were used to measure the predictor variables. SPSS statistical software has been used to analyze collected data. Binary logistic regression analysis was computed and variables with p-value < 0.25 were considered candidates for multivariable logistic regression. Adjusted Odds Ratios (AOR) with 95% confidence interval was estimated to identify the association. The statistical value was declared as a value of P < 0.05. Result: A sum of 88 stroke patients were engaged in the study with a response rate of 93.6%. The study found that, 39 (44.3%) patients had documented hyponatremia (either within 24hrs of admission, 24hrs to 14 days of admissions or both). The study revealed that patients who were given mannitol infusion treatment (AOR = 4.24, 95% CI: 1.08 16.6) and a proton pump inhibitor (AOR = 4.84, 95% CI: 1.33–17.5) were factors associated with hyponatremia. Conclusion: Hyponatremia is prevalent in acute stroke patients. Receiving mannitol infusion and proton pump inhibitors treatment were identified to be critically associated with hyponatremia among acute stroke patients. Therefore, the review implies a robust emphasis is needed to monitoring and therapeutically managing sodium levels among acute stroke patients. | |
| dc.identifier.uri | https://etd.aau.edu.et/handle/123456789/7666 | |
| dc.language.iso | en | |
| dc.publisher | Addis Ababa University | |
| dc.subject | Magnitude of Hyponatremia | |
| dc.subject | Associated Factors Among Acute | |
| dc.subject | Stroke Patients Admitted | |
| dc.title | Magnitude of Hyponatremia and its Associated Factors Among Acute Stroke Patients Admitted in Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia | |
| dc.type | Thesis |