Seroepidemiology of Toxoplasma Gondii infection and its risk factors in women of child-bearing age in selected health institutions of central Ethiopia

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dc.contributor.advisorDesta, Kassu (MSc)
dc.contributor.advisorDr.Sisay, Tesfaye(PhD)
dc.contributor.advisorZewda, Endras(PhD Candidate)
dc.contributor.authorHailu, Anteneh
dc.date.accessioned2021-09-07T07:42:37Z
dc.date.accessioned2023-11-06T08:56:57Z
dc.date.available2021-09-07T07:42:37Z
dc.date.available2023-11-06T08:56:57Z
dc.date.issued2012-06
dc.description.abstractBackground: Toxoplasmosis is an important zoonotic parasitic disease worldwide.Congenital transmission of T. gondii during pregnancy has been regarded as a risk factor for the health of newborn infants.Prevalence and risk factors of toxoplasmosis in women of childbearing age in Ethiopia are unknown. Objective: Estimating the seroprevalence and potential risk factors in acquiring T. gondii infection by women of child-bearing age in Central Ethiopia. Methods A cross-sectional study was conducted from May 2011 to January 2012 in child bearing age women of sample size of 425 in central Ethiopia. Indirect ELISA IgG and IgM test in parallel structured questionnaire was used to assess possible risk factors and knowledge and perception of health professionals about the disease. The data was cleaned, coded using Microsoft excel sheet and transferred to SPSS soft ware’s version 20 for data analysis. Results: The study revealed that anti-T. gondii antibodies were detected in 81.4% of the samples of which 69.4% were positive for only IgG and 12.0% positive for both IgG and IgM antibodies. Of the 213 pregnant women 57 (26.8%) were IgM reactive. Out of 17 potential risk factors investigated, univariable logistic regression showed significant association of T. gondii infection with study area, age, pregnancy status, raw vegetable consumption, source of water, presence of cat at home, contact with cat, HIV status and precaution during cats’ feces cleaning (P≤0.05). Almost all child bearing age women had no awareness or information regarding health risk of cats and toxoplasmosis. From health professionals, 63% (63) of them had knowledge of toxoplasmosis. Among health professionals 47.3% didn’t knew the importance of testing toxoplasmosis during pregnancy and (93%) do not screen pregnant women but 78% of them had an exposure of toxoplasmosis in patient and all of them didn’t gave health education. Conclusion: Results of current study showed that the seroprevalence of T. gondii infection in women of child-bearing age in central Ethiopia is high. Study area, pregnancy and raw vegetable consumption are risk factors to acquire T.gondii infection. Educational program, antenatal screening of pregnant women and further epidemiological studies to uncover the economic and health impact of toxoplasmosis are suggested.en_US
dc.identifier.urihttp://etd.aau.edu.et/handle/123456789/27819
dc.language.isoen_USen_US
dc.publisherAddis Abeba Universityen_US
dc.subjectToxoplasma gondii, Seroprevalence, Cross-sectional, Risk factors, Central Ethiopia,ELISA.en_US
dc.titleSeroepidemiology of Toxoplasma Gondii infection and its risk factors in women of child-bearing age in selected health institutions of central Ethiopiaen_US
dc.typeThesisen_US

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