Incidence and associated factors for post propofol induction hypotension during elective general surgery at Adama hospital medical college,Oromia ,Ethiopia,2020:a cross sectional study.
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Date
2020-11
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Addis Abeba University
Abstract
Background: Induction agents are drugs that, when given IV in an appropriate dose, cause a rapid
loss of consciousness. Propofol is a common anesthetic agent for the induction of general
anesthesia. During anesthesia, maintenance of adequate tissue perfusion is mandatory. However,
rapid infusion of propofol often causes hypotension.
Objectives: To determine the incidence and associated factors for hypotension after propofol
induction in patients undergoing general surgery from January to May 30, 2020 at Adama Hospital
Medical College.
Method: Institutional based cross sectional study was conducted on 286 on patients undergoing
general surgery from January, to May, 30, 2020 at Adama Hospital Medical College, Oromia,
Ethiopia using structured questionnaire. Systematic random sampling technique was used to select
the sample. Both binary and multiple variabe logistic regression analysis were done for associated
factors. Level of statistical significance was declared at p-value less than 0.05.
Results: The incidence of hypotension among clients undergoing general surgery after propofol
induction was 60.4%. Age >=60year AOR=3.01; 95%CI: (1.41- 6.41), baseline MAP 60100mmHg
AOR=3.78; 95%CI: (1.91-7.47), dose of propofol AOR= 2.40; 95%CI: (1.26-4.55),
dose of pethidine AOR=2.00; 95%CI: (1.09-3.69) were identified as associated factors of
hypotension among clients undergone general surgery after propofol induction.
Conclusion: Hypotension after propofol induction was a common problem in patients undergoing
general surgery. Age, baseline MAP, dose of propofol and pethidine are the clinical factors
associated with post-propofol induction hypotension. The use of these factors to estimate risk of
this hypotension might allow the avoidance and early treatments of hypotension during general
surgery.
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Keywords
Incidence, General surgery, Hypotension, Propofol, Oromia, Ethiopia