Risk Factors of Mortality among HIV/Tb Co-Infected Patients under Art: A Case Study in Change Health Center, Northwest Ethiopia
No Thumbnail Available
Date
2013-09
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Addis Abeba university
Abstract
HIV infection is a major risk factor for the development of tuberculosis (TB).
Tuberculosis is a cause of significant morbidity and mortality in patients with AIDS.
The objective of this study was to identify risk factors of mortality among HIV/TB
co-infected patients in Chagni Health Center, Awi zone in Amhara Regional State,
northwest Ethiopia. This is a retrospective study based on 510 cases of HIV-infected
TB patients of age 15 years and above who received anti-TB treatment between
September 1, 2010 and April 30, 2013 and were followed until July 31, 2013. The
Kaplan-Meier method was used to estimate survival time and Cox’s regression model
was employed to identify covariates that have statistical significant effects on the
survival of HIV/TB co-infected patients. The descriptive analysis showed that out of
510 patients, 200 (39%) patients died during ART and anti-TB treatment period, of
these 113 (56.5%) were females. 303 (59.4%) patients had ����4 ���������� ≤
200 ����������/������, 272 (53.3%) patients were in the age group (15 − 30), 265 (52.2%)
patients were under-weight (������ ≤ 18.5) and 234 (45.9%) patients started treatment
on D4T-based drug regimens. The results of the multivariate PH Cox regression
analysis showed that having cd4 count ≤ 200cels/mm3 at the start of ART,
presence of extra-pulmonary TB, being bedridden and WHO stage IV were
associated with higher risk of mortality. On the other hand, those patients who took
AZT-based drug regimens and having normal-weight (18.5 kg/m2 < bmil <
25 kg/m2 ) experienced lower risk of mortality.
Description
Keywords
Factors of Mortality among HIV