Simultaneous Determination of Dopamine and Pyridine-2- aldoxime methochloride at Poly (3, 4-ethylenedioxythiophene) Modified Glassy Carbon Electrode
| dc.contributor.advisor | Mehretie, Solomon (PhD) | |
| dc.contributor.author | Demeke, Abera | |
| dc.date.accessioned | 2018-06-11T12:06:34Z | |
| dc.date.accessioned | 2023-11-09T16:17:30Z | |
| dc.date.available | 2018-06-11T12:06:34Z | |
| dc.date.available | 2023-11-09T16:17:30Z | |
| dc.date.issued | 2016-03 | |
| dc.description.abstract | A sensitive and selective method was developed for the simultaneous determination of Dopamine (DA) and Pyridne-2-alidoxime methochiloride (PAM-2) with poly (3, 4- ethylenedioxythiophene) (PEDOT) modified glassy carbon electrode (GCE). Cyclic voltammetry and Square wave adsorptive stripping voltammetry (SWAdSV) were used to investigate the electrochemical reaction of DA and PAM-2 at the PEDOT modified electrode. DA and PAM-2 were showed a diffusion control and adsorption control reaction mechanisms, in phosphate buffer solution of pH 7.0 respectively. The significant anodic peak potential difference (525 mV) between DA and PAM-2 enabled the simultaneous determination of both species based on Square wave adsorptive stripping voltammetry. The voltammetric responses gave linear ranges of 5×10 −7 –1.0×10 −4 mol L −1 and 5.0×10 −6 –15.0×10 -5 molL −1 , with detection limits of 3.1×10 −8 molL −1 and 1.91×10 −7 molL −1 for DA and PAM-2, and The method was successfully applied for the determination of DA and PAM-2 in biological samples, with in a very good recovery result 101.57 % and 95.17 % respectively. Keywords: Dopamine (DA), Pyridine-2-aldoxime methochloride (PAM-2), Glassy carbon electrode (GCE), Poly (3, 4-ethylenedioxythiophene) (PEDOT), Cyclic voltammetry (CV) and Square wave adsorptive stripping voltammetry (SWAdSV) | en_US |
| dc.identifier.uri | http://etd.aau.edu.et/handle/12345678/347 | |
| dc.language.iso | en | en_US |
| dc.publisher | Addis Ababa University | en_US |
| dc.subject | Dopamine (DA); Pyridine-2-aldoxime methochloride (PAM-2); Glassy carbon electrode (GCE); Poly (3; 4-ethylenedioxythiophene) (PEDOT); Cyclic voltammetry (CV) and Square wave adsorptive stripping voltammetry (SWAdSV) | en_US |
| dc.title | Simultaneous Determination of Dopamine and Pyridine-2- aldoxime methochloride at Poly (3, 4-ethylenedioxythiophene) Modified Glassy Carbon Electrode | en_US |
| dc.type | Thesis | en_US |