Prevalence and Risk Factors for Cancer Associated Thrombosis (CAT)Among Patients Seen in TASH Clinical Oncology Department in One Year, (Sept 11, 2018 - Sept 10, 2019)Addis Ababa, Ethiopia.
| dc.contributor.advisor | Dr. Tigineh, Wondmagegnehu (MD,FC Rad Onc,SA). | |
| dc.contributor.author | Mitiku, Taddesse | |
| dc.date.accessioned | 2021-01-26T07:32:18Z | |
| dc.date.accessioned | 2023-11-05T09:35:06Z | |
| dc.date.available | 2021-01-26T07:32:18Z | |
| dc.date.available | 2023-11-05T09:35:06Z | |
| dc.date.issued | 2020-10 | |
| dc.description.abstract | Introduction: Cancer is prothrombotic. Thrombosis is common complication in patients with malignant disease.Cancer associated thrombosis is a major cause of mortality in cancer patients. It is the second leading cause of mortality in cancer patients. In a study done at Tikur Anbssa Specialized Hospital malignancy was number one cause of DVT. Objective: To determine prevalence of thrombosis in the general cancer population and specific cancers, to determine type of CAT, to identify Causes of CAT, and associated factors among patients seen in TASH Clinical Oncology Department in One year Methods: Retrospective descriptive analysis of CAT in all cancer patients seen in one year, from Sept 11, 2018_Sept 10, 2019 at TASH Clinical Oncology Department was conducted Result: A total of 177 patients with CAT was identified. 61.5% of them were females, and 38.42% were males. The prevalence of CAT in cancer patients was 5.47. Prevalence of CAT in female cancer patients was found to be 5.53% while it was 5.39% in males. Females were twice more likely to develop CAT than males with odds ratio 2.5 (CI 1.8332—3.4179), P <0.0001. CAT was most prevalent in, HCC (30.68%), genitourinary cancers (10.78%), brain tumor (10.74%), thyroid cancer (9.8%), thoracic tumors (9.0%). The three most common type of cancers associated with CAT in our set up were gynecologic cancers (29.4%), HCC (15.3%), GIT cancers (14.7%). Limb DVT was the commonest type of CAT (58.8%)identified followed by PVT (17.5%). Conclusion: The burden of CAT is significant in our cancer patients like it is all over the world. Gynecologic cancer, cervical cancer in particular was the most common type of cancer associated CAT cause of CAT. HCC was the second most common type of cancer associated with CAT. CAT was most prevalent in HCC. In this study it was found that there are significant number of incidentally detected portal vein thrombosis patients which were not treated nor on follow up for their thrombosis. Studies recommend that such patients should be managed similar to clinically detected patients. Recommendation: Emphasis should be given on prevention and treatment of CAT in cancer patients. We recommend active identification of CAT cases on high risk cancer patients. Discussion is recommended on how to go about incidentally identified CAT cases in general and PVT cases in particular. We strongly recommend further preferably prospective studies to address this important cause of morbidity and mortality in cancer patients. | en_US |
| dc.identifier.uri | http://etd.aau.edu.et/handle/123456789/24834 | |
| dc.language.iso | en_US | en_US |
| dc.publisher | Addis Ababa University | en_US |
| dc.subject | Cancer , Thrombosis ,Patients,Oncology | en_US |
| dc.title | Prevalence and Risk Factors for Cancer Associated Thrombosis (CAT)Among Patients Seen in TASH Clinical Oncology Department in One Year, (Sept 11, 2018 - Sept 10, 2019)Addis Ababa, Ethiopia. | en_US |
| dc.type | Thesis | en_US |