Establishment of Reference Intervals for the Common Renal and Liver Function Clinical Chemistry Parameters among Apparently Healthy Pregnant and non-pregnant women in South wollo zone, Amhara National Regional State, northeast Ethiopia.
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Date
2019-11
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Addis Ababa University
Abstract
Background: Physiological changes during pregnancy causes alterations in biochemicalanalytes concentration. Thus, pregnancy specific reference intervals (RI) are important foraccurate diagnosis and treatment of cases. In Ethiopia, clinical laboratory test results areusually interpreted using values established on western population.
Objective: To establish RIs for common renal and liver function clinical chemistryparameters among apparently healthy pregnant and non- pregnant women in South wollozone, Amhara National Regional State, northeast Ethiopia.
Methods: A community based cross sectional study was conducted on a total of 378apparently healthy study participants randomly selected from south wollo zone, Ethiopiafrom April to June 2019. Data like medical history, physical examination and sociodemographywere collected by using well organized questionnaire. After the exclusion ofoutliers using quartile method, Kolmogorov–Sminorv test was used to check its normality.The 95% RI with 95% confidence interval was established using the non-parametric
Method. The significance of differences between pregnant and non-pregnant women wasevaluated using Mann–Whitney U test.
Result: There was statistically significant variation between pregnant and non-pregnantwomen in values of Albumin, T.Protein, ALP, urea and Creatinine but not for AST, ALT,bilirubin(direct) and bilirubin(total). Reference intervals established for princludes: albumin 26.14–42.87g/l, total protein48.52–74.71 g/l, AST 2.4–43.6 U/L, ALT0.94–28.35 U/L, ALP 21.2–337 U/L, bilirubin(direct) 0.03-0.32 mg/dl, bilirubin(total) 0.26-0.94 mg/dl, creatinine 0.29–0.87 mg/dl, urea 7.17–20.82 mg/dl. Albumin: 32.81–47.87,total protein: 56.71–83.9 U/L, AST: 4.2–37.1 U/L, ALT: 2.69–41.18 U/L, ALP: 3.22–278.7U/L, bilirubin(direct) 0.1-0.51mg/dl, bilirubin(total) 0.24-1.06mg/dl, creatinine 0.44–1.00mg/dl, urea 8.07–27.87 mg/dl for non-pregnant women.
Conclusion: The RIs provided by this study are decisive in interpreting clinical laboratoryresults for medical decision making and other health-related conditions. Physiologicaladaptations of pregnancy should be taken into account when interpreting LFT and RFT in apregnant woman.
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This is to certify that the thesis prepared by Miftah MohammedAssen, entitled: Establishment of referenceintervals for the common renal and liver function clinical chemistry parameters among apparentlyhealthy pregnant and non-pregnant women in South wollo zone, Amhara National Regional State,northeast Ethiopia submitted in partial fulfillment of the requirements for Master of Science degree inClinical Laboratory Sciences (Clinical Chemistry track) complies with the regulations of the University and
meets the accepted standards with respect to originality and quality.
Keywords
Reference interval, Clinical chemistry, Biochemical analytes, South wollo, Healthy, pregnant, non-pregnant