Antidiabetic Activity of Ajuga Remota Benth (Harmegusa) Leaves in Streptozotocin Induced Diabetic Rats
| dc.contributor.advisor | Seifu, Daniel (PhD) | |
| dc.contributor.author | Assefa, Freshet | |
| dc.date.accessioned | 2018-06-21T07:38:31Z | |
| dc.date.accessioned | 2023-11-29T04:18:17Z | |
| dc.date.available | 2018-06-21T07:38:31Z | |
| dc.date.available | 2023-11-29T04:18:17Z | |
| dc.date.issued | 2013-08 | |
| dc.description.abstract | Ethnopharmacological relevance: The leaves of Ajuga remota (A. remota) have been utilized traditionally for the cure of diabetes mellitus and other ailments. Aim of the study: The present study was aimed to assess the antidiabetic activity of A. remota leaves extract in Streptozotocin (STZ) induced diabetic rats. Material and methods: Antidiabetic activity of the ethanol extracts of A. remota leaves (AREt) was studied in STZ induced diabetic rats. The effect of extract on fasting blood glucose, body weight, lipid profile, serum, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, urea, creatinine and total protein were analyzed. Glibenclamide was used as standard reference drug. Results: A. remota leaves ethanol extract (AREt) showed highly significant blood glucose lowering effect. After diabetic rats treated with AREt (200 and 400 mg/kg) for 28 days, there were a significant decrease in fasting blood glucose, total cholesterol, triacylglycerol, LDL- cholesterol, serum enzymes (alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase), and significant increase in body weight, serum total protein, HDL- cholesterol, levels as compared to untreated diabetic rats. Conclusion: The results of the experiments showed that A. remota leaves might be useful for management of diabetes mellitus and other abnormalities associated with this metabolic disorder. The present study might support the traditional use of A. remota for diabetes mellitus treatment. Key words: Ajuga remota, diabetes mellitus and streptozotocin | en_US |
| dc.identifier.uri | http://etd.aau.edu.et/handle/123456789/2557 | |
| dc.language.iso | en | en_US |
| dc.publisher | Addis Ababa University | en_US |
| dc.subject | Ajuga remota; Diabetes mellitus and Streptozotocin | en_US |
| dc.title | Antidiabetic Activity of Ajuga Remota Benth (Harmegusa) Leaves in Streptozotocin Induced Diabetic Rats | en_US |
| dc.type | Thesis | en_US |