Antidiabetic Activity of Ajuga Remota Benth (Harmegusa) Leaves in Streptozotocin Induced Diabetic Rats
No Thumbnail Available
Date
2013-08
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Addis Ababa University
Abstract
Ethnopharmacological relevance: The leaves of Ajuga remota (A. remota) have been utilized
traditionally for the cure of diabetes mellitus and other ailments.
Aim of the study: The present study was aimed to assess the antidiabetic activity of A. remota
leaves extract in Streptozotocin (STZ) induced diabetic rats.
Material and methods: Antidiabetic activity of the ethanol extracts of A. remota leaves
(AREt) was studied in STZ induced diabetic rats. The effect of extract on fasting blood
glucose,
body
weight,
lipid
profile,
serum,
alanine
aminotransferase,
aspartate
aminotransferase, alkaline phosphatase, urea, creatinine and total protein were analyzed.
Glibenclamide was used as standard reference drug.
Results: A. remota leaves ethanol extract (AREt) showed highly significant blood glucose
lowering effect. After diabetic rats treated with AREt (200 and 400 mg/kg) for 28 days, there
were a significant decrease in fasting blood glucose, total cholesterol, triacylglycerol, LDL-
cholesterol, serum enzymes (alanine aminotransferase, aspartate aminotransferase and
alkaline phosphatase), and significant increase in body weight, serum total protein, HDL-
cholesterol, levels as compared to untreated diabetic rats.
Conclusion: The results of the experiments showed that A. remota leaves might be useful for
management of diabetes mellitus and other abnormalities associated with this metabolic
disorder. The present study might support the traditional use of A. remota for diabetes
mellitus treatment.
Key words: Ajuga remota, diabetes mellitus and streptozotocin
Description
Keywords
Ajuga remota; Diabetes mellitus and Streptozotocin