Prevalence of extrapulmonary tuberculosis and rifampicin resistant in children at selected health facilities of South West Shewa Zone, Oromia, Ethiopia
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Date
2018-06
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Addis Ababa Universty
Abstract
Background: Tuberculosis (TB) is a chronic infectious disease that has long been one of the major health problems. It affects individuals of all ages and both sexes. Poverty, malnutrition and over-crowded living conditions have been known for decades to increase the risk of developing the disease .Extra pulmonary tuberculosis (EPTB) is an important clinical problem defined as the isolated occurrence of tuberculosis in any part of the body other than lungs. Aim of the study is to determine the Prevalence of EPTB Cases in children.
Objectives: Prevalence of Extra pulmonary Tuberculosis and Rifampicin Resistant in children at selected health facilities of South West Shewa Zone, Oromia, Ethiopia
Materials and Methods: A crossectional study was conducted from December 20, 2017- April 26 2018. A total of 416 samples (Pleural, Gastric lavage, CSF, Pus, Peritoneal fluid, Lymph node aspirate, Synovial fluid, and Ascitic fluids ) from patients with signs and symptoms of suggestive of tuberculosis at St.luke,Tullubolo,Ameya,Atat hospitals and Woliso, Dilela Health centers from December 20,20171, 2018 to April 26 25,2018 were recruited by consecutive sampling method. Extra pulmonary Tuberculosis samples were tested directly by Xpert MTB/RIF assay and MGIT and those extra pulmonary suspected samples were cultured for isolation and drug sensitivity testing of TB bacilli. Results with contaminated cultures (for both LJ and MGIT) were excluded from analysis. Data entry and analysis was done using SPSS statistical software version 20.
Result: Out of 416 body fluid specimens, 15.8% (66/416) were positive for MTB using Xpert MTB/RIF assay and no specimen were exhibited as a resistance to RIF. 10.57% 44/397) cases of Xpert MTB/RIF assay positive were MGIT positive, 3.12% (13/416) cases of Xpert MTB /RIF assay positive were MGIT negative and 2.2% (9/416) cases of Xpert MTB/RIF assay negative were MGIT positive .The most crucial risk factor that was significantly associated with extra pulmonary tuberculosis infection in this study was HIV.
Conclusion: There was a significant difference between GeneXpert results compared with Culture results. A significant proportion of EPTB cases were also co-infected with HIV.A more accurate test could contribute EPTB case detection, and thus reducing the morbidity and mortality
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Keywords
Liquid culture, extra pulmonary tuberculosis, rifampicin resistance