The Prognostic Value of Neutrophil to Lymphocyte Ratio in Sespsis Among Adult Emergency Patients at Tikur Anbessa Specialized Hospital (TASH) And Zewditu Memorial Hospital (ZMH) , Addis Ababa, Ethiopia
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Date
2025-12-12
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Addis Ababa University
Abstract
Background: - Sepsis Is Life-Threatening Condition Resulting from a Deregulated Immune Response to Infection with High Morbidity and Mortality Particularly in Low- And Middle-Income Countries Such as Ethiopia. The Significant Burden of Sepsis in Ethiopian Emergency Departments Underscores the Need for Improved Diagnostic Tools and Treatment Strategies. The Neutrophil-To Lymphocyte Ratio (NLR) Has Emerged as a Promising Biomarker That May Predict Clinical Outcomes in Sepsis, Yet Its Utility Is Ethiopian Context Remains Unexplored.
Objective: - The Prognostic Value of Neutrophil to Lymphocyte Ratio in Sepsis Among Adult Emergency Patients at Tikur Anbessa Specialized Hospital (TASH) Addis Ababa and Zewditu Memorial Hospital (ZMH), Ethiopia Multicenter Prospective Cross-Sectional Study
Methods: - The Study Was Conducted at TASH & ZMH In the Emergency Department. The Research Design Used for This Study Is Institutional-Based Prospective Cross-Sectional Study Design, Which Involves Collecting Data at Over 3 Months Period from Selected Sepsis Patients After Diagnosis by SOFA Guideline Admitted at the Emergency. The Data Were Collected from Aug 15- November 30, 2025, Through A Standard Checklist and Laboratory Results by a Data Collector.
Results: Among The Study Population, 58% Recovered While 42% Died. Non-Survivors Had Higher WBC Counts, Neutrophil Percentages, And Markedly Elevated NLR At Admission (24.52) Compared to Survivors (14.1). NLR After Treatment Remained Significantly Higher in Non-Survivors (28.99 Vs. 11.46). ROC Analysis Showed That NLR Had a Moderate Predictive Accuracy with an AUC Of 0.713 (95% CI: 0.618–0.808; P=0.000).
Conclusion: The Findings Align with Extensive Literature (21–30) Showing That Elevated NLR Is Consistently Associated with Poor Prognosis, Severity, And Increased Risk of Death. Routine NLR Monitoring May Enhance Early Risk Stratification and Guide Timely Clinical Interventions in Sepsis Care.
Work Plan – The Total Research Work from Title Selection to Presentation Was Completed In 6 Months
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Keywords
sepsis, NLR, mortality, prognostic value, biomarker, TASH, ZMH