Rate and predictors of endoscopic mucosal healing among IBD patients on medical therapy at Tikur Anbessa Specialized Hospital: Institution Based Prospective Cross-sectional study
| dc.contributor.advisor | Bane,Abate(Prof.) | |
| dc.contributor.advisor | Adem,Ahmed(MD) | |
| dc.contributor.author | Shibru,Habtewold | |
| dc.date.accessioned | 2025-08-13T07:46:36Z | |
| dc.date.available | 2025-08-13T07:46:36Z | |
| dc.date.issued | 2023-10 | |
| dc.description.abstract | Introduction Inflammatory bowel diseases (IBD) are characterized by chronic inflammation of the intestinal mucosa resulting from strong interaction between genetic, environmental, immunologic and intestinal microbial factors. Medical treatment for inflammatory bowel disease (IBD) has undergone a complete transformation over the last several decades due to the advent of different drugs. Clinical remission and endoscopic healing are integral components of the treat to target strategy in IBD therapy. Endoscopic healing is associated with significant reduction in complications of IBD and/or need for surgery. Objective The objectives of this study are to determine the rates of clinical remission and endoscopic mucosal healing among IBD patients on treatment and to sort out predictors of endoscopic healing. Methodology A prospective cross-sectional study was conducted at Tikur Anbesa Specialized Hospital from January, 2023 to October 2023. The study included all consecutive IBD patients on treatment for six months or more who showed up for a regular follow up at TASH GI clinic in the study period and who were willing to consent and undergo follow up colonoscopy. Results Overall Clinical remission rate from this Cross-sectional study is 69 /106, including 62/87, (71.3%) of CD, 7/17 (41.2%) of UC and 0 /2 Unclassified. Thirty-five (33%) of IBD patients in the study achieved endoscopic healing. Twenty-six of the 87 (29%) patients with CD, 8 of the 17(47%) UC, and one of the two with indeterminate colitis achieved endoscopic mucosal healing. Only 10 of the 32 CD patients with previous history of bowel resection achieved endoscopic healing. Higher ESR value (P = 0.040, AOR 0.946 with 95% CI 0.898-0.997) and younger age at diagnosis (P = 0.046, AOR 1.322 with 95% CI 1.005-1.739) predicted absence of endoscopic healing. Conclusion Sixty-nine of the one hundred six IBD patients (65.1%, 70% for CD, 41.2% for UC) were in clinical remission. The overall endoscopic mucosal healing rate from this study is 33% (29.1% CD, 47.1% UC). Elevated ESR and younger age at the diagnosis predicted absence of endoscopic healing within the study period. | |
| dc.identifier.uri | https://etd.aau.edu.et/handle/123456789/6659 | |
| dc.language.iso | en_US | |
| dc.publisher | Addis Ababa University | |
| dc.subject | Inflammatory bowel diseases | |
| dc.title | Rate and predictors of endoscopic mucosal healing among IBD patients on medical therapy at Tikur Anbessa Specialized Hospital: Institution Based Prospective Cross-sectional study | |
| dc.type | Thesis |