Treatmet Outcome and Pattern of Radiotherapy Utilization of Pediatrics Rhabdomyosarcoma at Tikur Anbessa Specialized Hospital; Ethiopia 5 Year Retrospective Study
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Date
2025-12-01
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Addis Ababa University
Abstract
Background: Rhabdomyosarcoma is the Most Common Pediatric Soft Tissue Sarcoma. In Low Income Countries RMS Treatment Is Challenging Unlike Improved Outcome in His. Unable To Get Timely Radiotherapy Access and Being Higher Stage Presentation for Surgery Is Main Determinate Factor for Inferior Outcome of Pediatric RMS In Sub-Saharan Countries Including Ethiopia. This Study Is Expected to Provide Valuable Insights About Current Pattern of RT Utilization and Treatment Outcomes.
Objective: The Study Aim was to Assess Treatment Outcomes and Pattern of Radiation Therapy Utilization, In Pediatrics RMS At TASH Between January 2021 and September 2025
Methods: Retrospective Cohort Study Was Conducted from January 2021 to September 2025 and 94 Eligible Patients Were Included. Data Collected from the Radiotherapy System and Chart of The Patients. Analysis Was Performed Using SPSS Version 25 Software and Kaplan-Meier Method Was Used to Estimate Survival. Cox Proportional Hazards Regression Analysis Was Done to Identify Independent Prognostic Factors Associated to Survival
Result: All Eligible 94 Patients Chart Analyzed, This Study Showed Majority of Them Are Embryonal Histology, Head and Neck Site, 44.7% Of Patients Received Radiotherapy With 33% Interruption and Delayed Interval from Chemotherapy. Estimated 24-Month Survival Time Is 18% And EFS 35%. Surgery And Radiotherapy Was Significantly Associated Independent Factor for Event Free Survival.
Conclusion: Children With RMS Present with Locally Advanced Stage. There Is Low Access of Local Treatment and RT Is Given After Delayed Time of Recommendation and Interruption. This Result Lower Local Control and Poor Survival.
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Keywords
Rhabdomyosarcoma, Radiotherapy utilization, Treatment outcome