Valuing health-state: an eq-5d-5l value set for Ethiopians
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Date
2018-11
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Addis Ababa Universty
Abstract
Background: There is a growing interest in health technology assessment and economic
evaluations in developing countries using measures such as EQ-5D-5L (European quality 5
dimension- 5 level). However, the main challenge is lack of local population value sets which are
recommended in most countries as they reflect local preferences.
Objective: To obtain social preference and establish an EQ-5D-5L value set from the Ethiopian
general population.
Methods: A sample reflecting urban, and rural population (n= 1,050) was recruited using stratified
multi-stage quota sampling technique. Face-to-face, computer-assisted interviews using the
EuroQol Portable Valuation Technology (EQ-PVT) software of composite time trade-off(c-TTO)
and discrete choice experiments (DCE) were undertaken to elicit preference score. The feasibility
of EQ-PVT was pilot tested in a sample of the population (n=110). A hybrid regression model
combining c-TTO and DCE data was used to estimate the final value set.
Results: The pilot study revealed that the feasibility of EQ-PVT protocol was good and there were
no special concerns with undertaking TTO task. The predicted value for the EQ-5D-5L ranged
from-0.7186 to 1. The coefficients generated from a hybrid model were logically consistent.
Anxiety/depression showed the most impact to utility decrement of 0.4578, and self-care
influenced the least 0.2224. The maximum predicted value beyond full health was 0.9741 for the
‘11112’ (health state of slight problem in anxiety/depression dimension).
Conclusions: This study established Ethiopian value set for EQ-5D-5L on the basis of c-TTO and
DCE. It is expected to facilitate health economic evaluations, health-related quality of life research
and to inform decision making in Ethiopia.
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Keywords
Discrete choice experiment, EQ-5D-5L, Ethiopia, Health state valuation, Quality of life, Time trade-off, Utility.