Carriage rate of nasal staphylococcus aureus and methicillin-resistant staphylococcus aureus and associated factors among diabetic patients at Tikur Anbessa Specialized Hospital Diabetic Clinic, Addis Ababa, Ethiopia

No Thumbnail Available



Journal Title

Journal ISSN

Volume Title


Addis Abeba University


Background: Currently the prevalence of diabetes mellitus is increased alarmingly in low and middle income countries. Concurrently the drug resistant S. aureus nasal carriage rate is increasing that may serve as a source of further infections in Diabetes mellitus patients. There is no study conducted on nasal carriage rate of S.aureus and Methicillin resistant S.aureus (MRSA) among diabetes patients in Ethiopia. Objective: The aim of this study was to assess the rate of nasal carriage of S.aureus and MRSA and associated factors among diabetic patients at Tikur Anbessa Specialized Hospital Diabetic Clinic, Addis Ababa, Ethiopia from January to June, 2018. Methods: A cross-sectional study was conducted from January to June, 2018. A total of 422 diabetic patients were recruited at TASH Diabetic Clinic. Nasal swab from the anterior nares was collected, and culture on both Manitol salt agar and blood agar. Antimicrobial susceptibility testing was done using disc diffusion method on Muller Hinton agar. Susceptibility to methicillin was phenotypically determined based on resistance of isolates to cefoxitin. Data was entered and analyzed using SPSS software version 20. Binary logistic regression analysis was used to assess the association of socio-demographic and associated factors for S.aureus culture isolates. P- value < 0.05 was considered as statistically significant. Results: The overall prevalence of S.aureus in the study was 47/422(11.1%). Majority of the S. aureus isolates were resistant to penicillin 46(97.8) on the other hand, all of the S. aureus isolates were sensitive to clindamycin. Multidrug resistance were shown in 4(6.2%) of the isolates. Of these, one MRSA was isolated from retire man who had uncontrolled glucose level with Type II DM despite insulin treatment and had foot wound. S.aureus isolation rate was significantly higher among DM patients who currently used combination of insulin and oral drug for diabetes mellitus treatment (odds ratio [AOR], 3.985, 95% CI, 1.270-12.437; p<0.017). None of the assessed socio-demographic factors showed a significant association with S.aureus nasal colonization. Conclusion: The nasal carriage rate of S.aureus among DM patients was low in this study. Also, the carriage rate of MRSA was very low in this study compared to other study; performing culture and sensitivity test for those DM patients would reduce the complication of infection. Further multicenter large scale studies should be conducted to identify the associated risk factors and antibiotic resistance pattern in diabetes mellitus patients.



Staphylococcus aureus, MRSA, diabetes mellitus patients