Assessment of Quality of Life among Children with Epilepsy and Associated Factors in Governmental Hospitals of Addis Ababa, Ethiopia,2021.

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Addis Ababa University


Abstract Background: Quality of life (QOL) is increasingly recognized as an important patient-reported outcome in health care research. However, the use is still restricted. Epilepsy impact was far more frequently evaluated considering QOL but only focused on adult patients so this research focused on children. Objective: To assess the quality of life among children between (7-18) with epilepsy and associated factors in governmental Hospitals in Addis Ababa, Ethiopia 2021. Methods: A facility-based cross-sectional study design was employed and data was collected from 564 children using a face-to-face interview in Addis Ababa from November 2020 to January 2021 selected using multi-stage sampling method. Probability proportionate to size technique was applied to select children from each hospital. The data was cleaned, entered through EPI-INFO 3.1and exported to STATA version 15.0 for analysis. Frequency distributions of variables were tabulated. The raw numbers of the five-point Likert scale for QOLIE-CH-48 domain scores were converted into a 0-100-point response scale, with higher scores indicating better QOL.ANOVA was used to assess the relationship between quality of life and the independent variables. Multiple linear regression was conducted to identify factors predicting quality of life. The threshold for statistical significance was p<0.05. Result: -A total of 564 children participated with a response rate of 94.1%. The mean score of quality of life was 60.18±8.68 (95% CI: 59.05, 61.23). Self-depression (P= 0.0094 F=3.39), number of anti-epileptic drug (AED) (P=0.0021 F=4.97), types of seizure (P= 0.000, F=52.26) were statistically significant predictors of QOL.A score in quality of life increased by 5.03 for every unit increase in a score of seizure frequency per week with (β= 5.0395% CI:0.4 - 0.9).Quality of life of epileptic patients increased by 0.19 and 1.99 in every unit increase in a score of stigma and anxiety (β= 0.1995% CI: (-0.1 - 0.1) and(β=1.99, 95%CI: 0.007- 1.03) respectively. Conclusion: -The quality of life among children with epilepsy was low. Stigma, seizure, depression and anxiety, and AED side effects were statically significant for quality of life. Implementing interventions that focus on early detection like self depression and stigma in children with epilepsy should be of great concern for healthcare providers.



Epilepsy, quality of life, children, Addis Ababa, hospitals