Association of Helicobacter pylori infection with Atopy and Allergic disorders in Ziway, Central Ethiopia
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Date
2017-05
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Addis Ababa University
Abstract
Background: Some epidemiological and experimental data point to the protective effect of
Helicobacter pylori infection against the development of many extra-gastric diseases,
including gastroesophageal reflux disease and its associated outcomes, childhood asthma and
allergy. There is scarcity of data concerning this in Ethiopia.
Objective: To assess the association of Helicobacter pylori infection with atopy and allergic
disorders in Ziway, Central Ethiopia
Methods and materials: Health facilities and school based cross sectional study was
conducted from October 2016 to January 2017, Ziway, Ethiopia. A total of 461 children were
enrolled in the study. Participant‟s socio-demographic and clinical information was collected
using International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire. Skin
prick test was done; blood and stool samples were collected from each participant.
Automated WBC and manual eosinophil count were performed from EDTA blood while total
serum IgE, H. Pylori stool antigen test and serum antibody test were determined using ELISA
technique. Descriptive statistics were used to express the socio-demographic characteristics
of the participants. Binary logistic regression was computed to assess association between
variables using SPSS version 20 for windows. P < 0.05 were taken as statistically significant.
Results: The overall prevalence of past and current H.pylori infection was 70.3% and 5.2%,
respectively. The overall prevalence of any sensitization was 2.4%. Our result also did not
show the protective effect of the bacteria. There was no association between past H.pylori
infection and atopic sensitization and allergic conditions (OR 1.58, 95% CI 0.44, 5.70
(P=0.48) and OR 0.96, 95% CI 0.56, 1.62 (P=0.86), respectively) and the current infection of
H. pylori was not associated with allergic conditions with OR 1.81, 95% CI 0.53, 6.22
(P=0.35). In this study the IgE levels were elevated in current H.pylori infected atopic
participants.
Conclusion: In this study we didn‟t find any significant association between past and current
H.pylori infection with atopy or allergic conditions. Further studies with high quality
longitudinal cohort are needed to map every possible correlates of the infection.
Keywords: Helicobacter pylori, Atopy, Allergy, IgE
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Keywords
Helicobacter pylori, Atopy, Allergy