Survival status and prognostic factors among breast cancer women at selected hospitals in southern Ethiopia, 2023.
| dc.contributor.advisor | Argaw,Zeleke(Ass. prof.), Dugussa,Boka(Lecturer) | |
| dc.contributor.author | Desta,Bitsiet | |
| dc.date.accessioned | 2024-04-23T11:00:47Z | |
| dc.date.available | 2024-04-23T11:00:47Z | |
| dc.date.issued | 2023 | |
| dc.description.abstract | Introduction: Breast cancer is the major cause of morbidity and mortality worldwide, particularly in countries with limited resources. Patients in developing countries, particularly Ethiopia, are less likely to survive due to delayed diagnosis and advanced- stage presentations. Several studies have been conducted on the prognostic factors among breast cancer patients in Ethiopia, but they cannot consider neutrophils to lymphocytes as the prognostic factor. Objective: To assess the survival status and prognostic factors among Breast Cancer womenat selected hospitals in southern Ethiopia,2023. Methods: A retrospective cohort studywas conducted among 507 randomly selected breast cancer women in selected hospitals in southern Ethiopia.Two trained BSc nurses collected the data using an open data kit (ODK).Descriptive statistics were summarized using tables and graphs. The bivariable and multivariable Weibull regression modelswere used to identify the prognostic factors. The final model fitness was investigated using the Cox-Snail residual test, and the Schoenfeld residuals test was used to examine the proportional hazards assumption. Results:The overall survival of breast cancer women at the end of two and three years was 54.5% and 23.9%, respectively. An excellent and good Nottingham prognostic score (AHR: 0.26, 95% CI: 0.12, 0.53) and (AHR: 0.39, 95% CI: 0.18, 0.81), chemotherapy (AHR: 0.59, 95% CI: 0.36, 40.93), metastasis (AHR: 1.89, 95% CI: 1.31, 2.74), advanced stages (AHR: 1.73, 95% CI: 1.19, 2.51), hormone therapy (AHR: 0.64, 95% CI: 0.44, 0.92), and lower neutrophil to lymphocyte ratio (AHR: 0.68; 95% CI: 0.47; 0.97) were the prognostic factors of breast cancer women. Conclusion: This study revealed that the breast cancer survivorship rate was lower than that of an earlier study from Ethiopia. An increased ratio of neutrophils to lymphocytes at the time of diagnosis and a poor NPI were linked to a worse chance of survival for breast cancer women; this indicated that promoting early diagnosis of breast cancer and treatment could be important to improve the survival of breast cancer patients. | |
| dc.identifier.uri | https://etd.aau.edu.et/handle/123456789/2832 | |
| dc.language.iso | en_US | |
| dc.publisher | Addis Ababa University | |
| dc.subject | Breast cancer, survival, prognostic factors | |
| dc.title | Survival status and prognostic factors among breast cancer women at selected hospitals in southern Ethiopia, 2023. | |
| dc.type | Thesis |