Prevalence of Rhesus Negative Gene among pregnant women and Assessment of Effective Management of RH Negative pregnancy in Gandhi Memorial Hospital, Addis Ababa, Ethiopia

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Addis Abeba Universty


Introduction: Despite the introduction and widespread use of Rhesus (Rh) D immunoglobulin for prevention of hemolytic disease of the fetus/newborn (HDFN), Rh alloimmunization remains a significant problem in perinatology. Care management with anti-D prophylaxis in patients presenting with severe alloimmunization is difficult to access in Sub-Saharan Africa. Objective: This study aims to determine the prevalence and assess the existing mechanism for management of Rh negative pregnant women in Gandhi Memorial hospital. Methods: A cross sectional study using quantitative and qualitative methods was used in the study. A total of 497 women case files were included in the study from September, 2012 to August, 2014 to determine the prevalence by using systematic random sampling. Then another 384 case files of Rh negative women was included by simple random sampling for assessment of the management of Rh negative pregnancy. SPSS was used for data entry and analysis .Tables were used to show the results, percents and frequencies to describe the variables. Univariate and Bivariate analysis using Chi square was conducted and p value was determined. In the qualitative method in-depth interview with 7 key informants by using purposive sampling, to assess the availability and affordability issues of medication was done. Data was analyzed as per the procedure i.e. recording, transcribing, translation and organizing and content analysis was conducted using open code software. Result The prevalence of Rh negative was 7.2% with 95%CI (6.9, 7.5). The utilization rate of Anti D was 14.3%. There was 4.7% offer of RAADP at 28 weeks. Regarding Anti D administration all socio demographic factors included in the study were not statistically significant with anti D administration. Qualitative data suggest that special consideration is necessary on this issue Conclusion and Recommendation The prevalence of Rh negative women is of a high magnitude keeping in view the prevalence rate of the other African countries estimate. There is lack of proper management of Rh negative pregnant women. Special attention should be given to Rh negative pregnancy to be included in maternal health programs by Ministry of health, donors and other collaborators.



Prevalence of Rhesus Negative Gene among pregnant women