Determination of community based reference interval of selected clinical chemistry parameters among apparently healthy Adolescents in Mekelle City, Tigray North Ethiopia from December 2018 to May 2019, and Community based cross sectional study.
| dc.contributor.advisor | Wolde, Mistire(MSc, PhD and Aassociate prof) | |
| dc.contributor.advisor | Tsegaye, Aster(MSc, PhD and Associate prof) | |
| dc.contributor.author | Belay, Getachew | |
| dc.date.accessioned | 2020-05-21T19:01:08Z | |
| dc.date.accessioned | 2023-11-06T08:56:34Z | |
| dc.date.available | 2020-05-21T19:01:08Z | |
| dc.date.available | 2023-11-06T08:56:34Z | |
| dc.date.issued | 2019-06 | |
| dc.description.abstract | Background: Clinical laboratory reference intervals (RIs) are essential for clinical diagnosis, treatment and therapeutic monitoring. Locally established RIs are required to correctly interpret clinical laboratory results. In Ethiopia, particular in Tigray region, clinical laboratory test results are interpreted based on RIs derived from a western population. Objective: To establish reference interval of clinical chemistry parameters among apparently healthy adolescents aged between 12 and 17 years in Mekelle, Tigray northern part of Ethiopia. Method: Community based cross sectional study was employed from December 2018 to May 2019 in Mekelle city among 172 males and 172 females based on Multi stage sampling technique. Blood samples were tested for Fasting blood sugar (FBS), alanine aminino transferase (ALT), aspartate amino transferase (AST), alkaline phosphatase (ALP), Creatinine, urea, total protein, albumin (ALB), direct bilirubin (BIL.D) and total bilirubin (BIL.T) clinical chemistry parameters using the 25 bio system clinical chemistry analyzer. Results were analyzed using SPSS version 23 software and based on the Clinical laboratory standard institute (CLSI)/ International Federation of Clinical Chemistry (IFCC) C 28-A3 Guideline which defines the reference interval as the 95% central range of 2.5th and 97.5th percentiles. Mann Whitney U test, descriptive stastics and box and whisker were stastical tools used in analysis of the study. Result: This study observed statistically significant differences between males and females in ALP, ALT, AST, Urea and Creatinine Reference intervals. The established reference intervals for males and females, respectively, were: ALP (U/L) 79.48-492.12 versus 63.56-253.34, ALT (U/L) 4.54-23.69 versus 5.1-20.03, AST 15.7- 39.1 versus 13.3- 28.5, Urea (mg/dL) 9.33-24.99 versus 7.43-23.11, and Creatinine (mg/dL) 0.393-0.957 versus 0.301-0.846. The combined RIs for Total Protein (g/dL) was 6.083-7.85, ALB (g/dL) 4.42-5.46, FBS(mg/dL) 65-110, BIL.D (mg/dL) 0.033-0.532, and BIL.T (mg/dL) 0.106-0.812. Conclusion: The result showed marked difference among sex for selected clinical chemistry parameters. It also differs from company derived values. Thus, establishing age and sex specific reference intervals locally and nation wide for clinical chemistry parameters is recommended. | en_US |
| dc.identifier.uri | http://etd.aau.edu.et/handle/123456789/21283 | |
| dc.language.iso | en_US | en_US |
| dc.publisher | Addis Ababa University | en_US |
| dc.subject | Reference interval, Adolescent, Clinical Chemistry, Ethiopia | en_US |
| dc.title | Determination of community based reference interval of selected clinical chemistry parameters among apparently healthy Adolescents in Mekelle City, Tigray North Ethiopia from December 2018 to May 2019, and Community based cross sectional study. | en_US |
| dc.type | Thesis | en_US |