Assessment of Liver and Renal Function Tests among Patients with Typhoid Fever in Motta General Hospital, Northwest Ethiopia
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Date
2024-07-15
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Addis Ababa University
Abstract
Background: Typhoid fever is a systemic infection caused by salmonella typhi. Oro-fecal contamination is a common route of entry to cause infection of the gastrointestinal system. The bacteria then burrow the walls of the intestines and cause bacteremia through a profusion of bacteria in a person’s bloodstream, which invade the liver, kidney, and other organs. In addition to the systemic infection, the liver organ can exposed to the bacteria directly via the gut-liver axis (enterohepatic circulation). Typhoid hepatitis and renal damage are the atypical presentations of typhoid fever. Lack of sensitive and specific diagnosis tests leads to poor clinical management of typhoid fever.
Objective: To assess liver and renal function tests among typhoid fever patients in Motta General Hospital, Northwest Ethiopia 2023.
Method: Institutional-based comparative cross-sectional studies were conducted at Motta General Hospital from May to December 2023 among 90 typhoid fever cases and 90 control groups who were selected with a convenient sampling technique. Laboratory tests were performed by the principle of spectrophotometry method to measure liver and renal function tests. Data entry and analysis were done by SPSS version 26. A p-value.
Results: The mean age of typhoid fever and control subjects were 33.10± 12.11 years and 32.62 ± 7.708 respectively. The levels of serum AST, ALT, ALP, TB, DB, and creatinine showed statistically significant d Conclusion: The findings of this study showed that liver function tests(ALT, AST, ALP, TB, and DB) and renal function tests(creatinine) were significantly altered by typhoid fever as compared with the control group, which would play an essential role in the management of typhoid fever.
Keywords: Typhoid fever, liver function test, renal function testifferences between typhoid fever and control groups .
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Assessment of Liver and Renal Function Tests among Patients with Typhoid Fever in Motta General Hospital, Northwest Ethiopia