Assessment of RFT, serum total protein, lipid profile tests and associated risk factors among pregnant women with pregnancy-induced hypertension attending in Asrade Zewudie Memorable hospital (ASZMPH), Gojjam, Ethiopia: Case-control study.
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Date
2020-06
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Addis Abeba University
Abstract
Background: - Pregnancy-induced hypertension has remained a significant global public health
threat in both developed and developing countries. Therefore, this study aims to assess renal
function tests, serum total protein, lipid profile tests and associated risk factors among pregnant
women with pregnancy-induced hypertension attending in Asrade Zewudie Memorable hospital
(ASZMPH), Gojjam, Ethiopia: Case-control study.
Methods: - A prospective case control study was done from January 24, 2020, to April 30,
2020. 200 pregnant women were recruited; 100
with pregnancy induced hypertension (case group) and 100 normotensives (control group). 5 ml
of venous blood was collected on the SST test tube and analyzed for lipid profile, renal function
and serum total proten using standard enzymatic methods, modified Jaffe method, urease and biu
ret method respectively. The analysis was done by using SPPS software (version 20.0). Finally,
the result was interpreted by using chi-square, Pearson's correlation, and multivariate logistic
regression. The level of statistical significance was set at a 95% confidence interval and those
variables in which P-value is less than 0.05 were considered clinically significant.
RESULTS:- In the present study, there was a significant increase in the serum level of serum
total cholesterol, triglyceride, blood urea, serum creatinine, and low density lipoprotein (p <
0.05) and a significant decrease in high density lipoprotein in case groups as compared to normal
groups (p < 0.05). The level of serum total protein was almost similar between the two groups
even if the level was somewhat high in cases. However, the elevation of serum total protein was
not significant (p >0.05). Factors like body mass index (BMI) >24.9 k/m
2
, absence of scheduled
exercise, alcohol, did not consume enough fruit, to be in the 3
rd
trimester and pregnant women
with multigravidia status have significant association with abnormal results of lipid profile tests
relative with the reveres one. Factors like BMI >24.9 k/m
2
and multigravidia were have
significant association with blood urea nitrogen and serum creatinine test results. Also pregnant
women's in the third trimester have more chance to have abnormally low serum total protein
compared with pregnant women in the second trimester in both groups(P< 0.05).
CONCLUSION: - The findings of the present study indicated that abnormal results of lipid
profile and RFT were significantly associated with pregnancy induced hypertension. Also
pregnant women's with body mass index >24.9 k/m
2
,not doing scheduled exercise, drunks
alcohol, not consuming fruit, in the 3
rd
trimester, and with multigravidia were have high
significant chance to have abnormal results of lipid profile test, renal function test and serum
total protein relative with the opposite one. So it will better if clinicians use lipid profiles and
renal function tests as screening test than requesting other costly tests. Further studies in different
areas of the country by considering life style variation also recommended.
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Keywords
Lipid profile, serum total protein, renal function test, PIH, and Ethiopia