Assessment of RFT, serum total protein, lipid profile tests and associated risk factors among pregnant women with pregnancy-induced hypertension attending in Asrade Zewudie Memorable hospital (ASZMPH), Gojjam, Ethiopia: Case-control study.

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Date

2020-06

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Addis Abeba University

Abstract

Background: - Pregnancy-induced hypertension has remained a significant global public health threat in both developed and developing countries. Therefore, this study aims to assess renal function tests, serum total protein, lipid profile tests and associated risk factors among pregnant women with pregnancy-induced hypertension attending in Asrade Zewudie Memorable hospital (ASZMPH), Gojjam, Ethiopia: Case-control study. Methods: - A prospective case control study was done from January 24, 2020, to April 30, 2020. 200 pregnant women were recruited; 100 with pregnancy induced hypertension (case group) and 100 normotensives (control group). 5 ml of venous blood was collected on the SST test tube and analyzed for lipid profile, renal function and serum total proten using standard enzymatic methods, modified Jaffe method, urease and biu ret method respectively. The analysis was done by using SPPS software (version 20.0). Finally, the result was interpreted by using chi-square, Pearson's correlation, and multivariate logistic regression. The level of statistical significance was set at a 95% confidence interval and those variables in which P-value is less than 0.05 were considered clinically significant. RESULTS:- In the present study, there was a significant increase in the serum level of serum total cholesterol, triglyceride, blood urea, serum creatinine, and low density lipoprotein (p < 0.05) and a significant decrease in high density lipoprotein in case groups as compared to normal groups (p < 0.05). The level of serum total protein was almost similar between the two groups even if the level was somewhat high in cases. However, the elevation of serum total protein was not significant (p >0.05). Factors like body mass index (BMI) >24.9 k/m 2 , absence of scheduled exercise, alcohol, did not consume enough fruit, to be in the 3 rd trimester and pregnant women with multigravidia status have significant association with abnormal results of lipid profile tests relative with the reveres one. Factors like BMI >24.9 k/m 2 and multigravidia were have significant association with blood urea nitrogen and serum creatinine test results. Also pregnant women's in the third trimester have more chance to have abnormally low serum total protein compared with pregnant women in the second trimester in both groups(P< 0.05). CONCLUSION: - The findings of the present study indicated that abnormal results of lipid profile and RFT were significantly associated with pregnancy induced hypertension. Also pregnant women's with body mass index >24.9 k/m 2 ,not doing scheduled exercise, drunks alcohol, not consuming fruit, in the 3 rd trimester, and with multigravidia were have high significant chance to have abnormal results of lipid profile test, renal function test and serum total protein relative with the opposite one. So it will better if clinicians use lipid profiles and renal function tests as screening test than requesting other costly tests. Further studies in different areas of the country by considering life style variation also recommended.

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Keywords

Lipid profile, serum total protein, renal function test, PIH, and Ethiopia

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