Adherence to Adjuvant Hormonal Therapy and Associated Actors Among Women with Breast Cancer Attending at Tikur Anbessa specialized hospital, Addis Abeba, Ethiopia, 2019.
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Date
2019-06
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Addis Ababa University
Abstract
Background: Breast cancer is one of leading cause of morbidity and mortality in Ethiopia.Adjuvant hormonal therapy (AHT) is one of the treatment modality given for a patient withbreast cancer with estrogen receptor positive after primary treatment for 5-10 years. Nonadherence to adjuvant hormone therapy
inbreast cancer survivors is commonand associated with increased risk of recurrence of cancer,invade the other breast,and consequently increase morbidity and mortality.
Objective:Toassess level of adherence to adjuvant hormonal therapy and associated factors amongwomen with breast cancer who attends oncology outpatient at Tikur AnbessaSpecialized Hospital.
Method: Institutional based cross-sectional study was conducted. Convenience sampling technique was used to select 216 participants. A semi-structured questionnaire was used after some modifications and Morisky Medication Adherence Scale (MMAS-8). Data were enteredin EpiData version 4.4.2.1 and exported to SPSS version 24, and analyzed using ordinal logistic
regression with OR and 95%CI.
Result: Out of 216, 209 women with breast cancer participated in the study with response rate of 97%. The level of adherence was 41%, 33%, and 26% for low, medium and high adherence respectively. Age group <45 is likely to be high adherence compared to >65 with (OR= 2.6,CI (3.8-7.6) p-value 0.001); being from urban (OR= 1.5, CI (1.1-2.8, p-value 0.001); being on
tamoxifen (OR= 1.6, CI (0.4-2.2), p-value 0.005); having side effect (OR= 1.5, CI (0.4-1.9), pvalue 0.004); comorbidity (OR= 1.6, CI (1.5-3.4, p-value 0.001) and Getting a thorough therapeutic communication (OR= 1.7, CI (1.2-3.2), p-value 0.001) were found to be significantly associated with adherence to AHT.
Conclusions and recommendations: In summary, the high adherence level to AHT among women with breast cancer was 26% in Tikur Anbessa Specialized Hospital. Age, place of residence, types of AHT, side effect, comorbidity, therapeutic communication from health care providers were significantly associated with adherence. Healthcare provider should give health education concerning medication usage, management of side effects and should also give due attention to rural patient.
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Adherence, Adjuvant Hormone Therapy, Breast Cancer, Ethiopia