Antibiotic Susceptibility Pattern of Neisseria Meningitides Isolates From Asymptomatic Carriers in Gurage Zone, Southern Ethiopia
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Date
2017-06
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Addis Abeba university
Abstract
Background: Neisseria meningitides represents a pathogen of great public health importance inboth developed and developing countries. Resistance to some antimicrobial agents used eitherfor therapy of invasive infections or for prophylaxis of case contacts has long been recognized.However, there is a limited data in relation with the antimicrobial resistance pattern of Neisseriameningitides in Ethiopia. Therefore; the aim of this study was to assess drug susceptibilitypattern of Neisseria meningitides isolates from asymptomatic carrierers of all age groups atMeskan and Mareko Districts, Gurage Zone, Southern Nations, Nationalities and PeoplesRegional State Ethiopia.
Methods: Cross-sectional study was conducted on 187 Neisseria meningitides isolates obtainedfrom MenAfricar project.A total of 4110 study participants from Meskan and Mareko Districts,Gurage Zone, Southern Nations, Nationalities and Peoples Regional State, Ethiopia werescreened for Neisseria meningitides by the project. Antimicrobial susceptibility test (AST) wasdone on stored Neisseria meningitides isolates.The activity of ten antimicrobial agents used fortreatment and prophylaxis of meningococcal disease was investigated. The AST was performedfor Neisseria meningitides isolates according to the criteria of the CLSI guide line by diskdiffusion method. Data was analysed by using SPSS version 20.0 software.
Results: From 187 Neisseria meningitides isolates 8(4.28%) were serogroup X, 24(12.83%)were serogroup Y, 1(0.53%) was serogroup W135 and 154(82.35%) were non determinant (ND).Resistance for Cotrimoxazol was high accounting 116(62%) followed by Ciprofloxacine112(60%), Cefotaxime 26(14%), Ceftriaxone 24(13%) , Meropenenem 21(11%) , Minocycline15(8%), Rifampine 14(7.5%), Azithromycine 10(5%), Chloramphenicol 7(4%),Levofloxacin6(3%) . 102(54.5%) isolates were resistance for more than one drug.
Conclusions: An antimicrobial resistance for Neisseria meningitides isolates from asymptomaticcarriers for the present study is high. Continued surveillance of meningococci for antimicrobialresistance is necessary to monitor early detection of changes in susceptibility patterns that mightaffect recommendations for chemoprophylaxis and treatment.
Key words: Neisseria meningitides, serogroups, sensitivity pattern, drug resistance
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Keywords
Neisseria Meningitides;Serogroups;Sensitivity Pattern;Drug Resistance