Magnitude of H.pyloriinfection and its association with Pre-eclampsia among pregnant women attending antenatal care at Gandhi memorial hospital Addis Ababa, Ethiopia.
No Thumbnail Available
Date
2021-09
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Addis Abeba University
Abstract
Background:Helicobacter pylori infections are associated with many complications of
pregnancy including preeclampsia and itcolonizes the gastric mucosa of about half of the world‟s
population. It has been suggested that Helicobacter pylori infection could contribute to the etiopathogenesis
of pre-eclampsia by inducing a pro-inflammatory state. The association H.
pylori with preeclampsia needs to be further explored.
Objective:To assess magnitude of H. pylori infection and its association with preeclampticpregnant
women attending antenatal care at Gandhi Memorial hospital Addis Ababa,
Ethiopia, 2021.
Methods:Hospital-based case control study was conducted amongclinicallydiagnosed preeclamptic
and Non-pre eclamptic pregnant women at Gandhi Memorial Hospital, Addis Ababa,
Ethiopia. Stool samples were collected for H. pyloriantigen test from study participants. The
collected data was analyzed using statistical methods in SPSSversion23. Simple descriptive
statistics was used to present the socio-demographic and clinical characteristics of the study
subjects. Association between Clinical variables and H. pyloriinfection was performed with
multivariate logistic regression. A p-value of <0.05 at 95% confidence level was considered as
statistically significant in all the analyses.
Result:A total of 93 cases and 186 controls were included in the study giving that a response rate
of 92(98.9%) and 180(96.8%) from all participants that included in the study respectively. In this
study, the overall prevalence of H. pyloriinfection in all study participants was 38.9% (106/272).
The prevalence of H. pyloriinfection was higher in cases than controls, 54.3% (50/92) vs. 31.1%
(56/180) respectively. The mean age was 29.01(SD+4.93) years in cases and 30.37(SD+ 6.2)
yeas in control group. Ages 26-35 years accounted for the majority proportion for both cases 62
(67.4%) and controls 128 (71.1%). A positive association was found between H. pylori infection
and Preeclampsia (OR: 2.64; 95% CI: 2.41–4.10).
Conclusion: H. pylori infection has been found to be associated with preeclampsiawomen. In
this study, the prevalence of H. pylori infection was higher in cases than in controls (which was
54.3% vs. 31.1% respectively. “Parity, systolic blood pressure and status of hemoglobin were
significantly associated with pre eclamptic women with H-pylori”.Key words:Helicobacter
pylori, Pre-eclampsia, Pregnant women
Description
Keywords
H.pyloriinfection,Pre-eclampsia,Pregnant women,Antenatal care