Assessment of Platelet Count in Malaria Suspected Patients in Adama Referral Hospital, Adama, Ethiopia
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Date
2021-05
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Addis Abeba University
Abstract
Background: A higher risk of thrombocytopenia was identiļ¬ed in malaria patients with
severe anemia, neurologic complications, pulmonary complications, liver dysfunction,
renal impairment and severe hypoglycemia. However, there is limited information
regarding platelet parameters abnormality associated with malaria infection in Ethiopia.
Objective: The objective of this study was to asses platelet count in malaria suspected
patients in Adama Referral hospital, Adama.
Method: In this cross-sectional study which was conducted from February to September
2020, 442 malaria suspected patients were selected using convenient sampling technique.
Data was collected using interviewer administered pre-tested questionnaire and clinical
data was obtained from patient medical record. Complete blood count was performed
using Beckman Coulter (DXH800) automated hematology analyzer and finger prick
capillary blood was used for microscopic examination of malaria. Data was entered and
analyzed by using (SPSS) version 24. Descriptive statistics was applied to determine the
mean, frequencies, and percentages of the study parameters. Pearson correlation analysis
and regression analysis was performed to see significance association between variables
P value less than 0.05 was considered statistically significant.
Result: Of the 422 malaria suspects majority 206 were (48.8%)in the age group of 20-40
and 214 (50.7 %) were females. The overall magnitude of malaria was 23.9% (101/422)which is 56(26.9%) and 45(21.0%) in males and females, respectively. The overall
magnitude of thrombocytopenia was 77(18.2%). Among thrombocytopenic patients,
55(71.4%) were positive for malaria. Magnitude was higher in P. vivax patients. There
was negative correlation between parasite density and platelet count (r=-0.539 P=0.01)as well as with neutrophil % (r=-0.374 P=0.01).lymphocyte count % and parasite density
had positive (r= 0.476 P=0.01)lymphocyte count # and parasite density had positive
correlation (r=0.236 P=0.05).
Conclusion:The magnitude of thrombocytopenia was higher among malaria positive than
negative patients and it was relatively more common among P. vivax than P. falciparum
infected patients.
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Keywords
Thrombocytopenia, Malaria, Complete Blood Count, Adama, Ethiopia