Pattern and Factors associated with Congenital Anomalies among NICU admitted Neonates in TASH: Case-Control study
| dc.contributor.advisor | Tesfaye,Edomgenet ( MD,Ass.Prof.) | |
| dc.contributor.author | Asfaw,Hewan | |
| dc.date.accessioned | 2025-08-12T16:59:30Z | |
| dc.date.available | 2025-08-12T16:59:30Z | |
| dc.date.issued | 2024-03 | |
| dc.description.abstract | Background: Congenital anomalies have imposed a sizable burden on global mortality, disability and medical cost worldwide. Several studies have investigated the risk factors attributed to lethal congenital anomalies Objective: To assess pattern and associated factors of congenital anomalies, in neonatal intensive care unit, Tikur Anbessa specialized hospital, Addis Ababa, Ethiopia 2023 Methodology: The case-control study was employed to investigate factors associated with congenital anomalies at Tikur Anbesa Specialized hospital. Cases included all newborns with congenital anomalies admitted to the ICU, while controls were randomly selected unmatched newborns without congenital anomalies. The normal distribution of continuous variables was assessed using Shapiro-Wilk test. The mean and standard deviation calculated for normality distributed data while median and interquartile range calculated for skewed data. A univariate and multivariate binary logistic regression analysis was performed to examine the factors associated Congenital anomalies. The results of logistic regression reported as adjusted odds rations (OR) with 95% confidence intervals and p-value < 0.05 are considered statistically significant. Results: An analysis involving 131 cases and 128 controls revealed that the median age of mothers stood at 28(±IQR= 6) years. Respiratory anomalies were identified as the most common, accounting for 21.4 % of the cases, followed by multiple congenital anomalies at 20.6 %, and gastrointestinal anomalies at 19.8 % of cases. After adjusting for all variables in the multivariate analysis, folic acid supplementation was found to have a significant impact on preventing congenital anomalies (AOR=0.58, 95% CI 0.3, 0.99, p=0.032). Further analysis of the data revealed that maternal age over 35 years (AOR=2.3, 95% CI 0.8, 6.5, p=0.12), maternal smoking (AOR=6.7, 95% CI 0.8, 58.1, p=0.08), a history of previous congenital anomalies (AOR=2.1, 95% CI 0.4, 11.8, p=0.4), exposure to environmental toxins (AOR=0.2, 95% CI 0.3, 3.8, p=0.78), maternal alcohol consumption (AOR=2.4, 95% CI 0.6, 9.6, p=0.21), and maternal chronic medical conditions (AOR=1.8, 95% CI 0.7, 4.4, p=0.23) were non-statistical positive association with congenital anomalies. Conclusion: Numerous factors have been linked to the occurrence of congenital anomalies. The pattern of these anomalies differed from those found in other local studies and global evidence, despite similar contributing and aggravating factors. | |
| dc.identifier.uri | https://etd.aau.edu.et/handle/123456789/6352 | |
| dc.language.iso | en_US | |
| dc.publisher | Addis Ababa University | |
| dc.subject | Congenital Anomalies | |
| dc.subject | NICU | |
| dc.subject | Neonates | |
| dc.title | Pattern and Factors associated with Congenital Anomalies among NICU admitted Neonates in TASH: Case-Control study | |
| dc.type | Thesis |