Pattern and Factors Associated with Congenital Anomalies among NICU Admitted Neonates in TASH: Case-Control study
| dc.contributor.advisor | Tesfaye Edomgenet | |
| dc.contributor.author | Asfaw Hewan | |
| dc.date.accessioned | 2025-08-12T16:59:30Z | |
| dc.date.available | 2025-08-12T16:59:30Z | |
| dc.date.issued | 2024-03 | |
| dc.description.abstract | Background: Congenital anomalies have imposed a sizable burden on global mortality,disability and medical cost worldwide. Several studies have investigated the risk factors attributed to lethal congenital anomalies Objective: To assess pattern and associated factors of congenital anomalies, in neonatalintensive care unit, Tikur Anbessa specialized hospital, Addis Ababa, Ethiopia 2023 Methodology: The case-control study was employed to investigate factors associated withcongenital anomalies at Tikur Anbesa Specialized hospital. Cases included all newborns withcongenital anomalies admitted to the ICU, while controls were randomly selected unmatchednewborns without congenital anomalies. The normal distribution of continuous variables wasassessed using Shapiro-Wilk test. The mean and standard deviation calculated for normalitydistributed data while median and interquartile range calculated for skewed data. A univariateand multivariate binary logistic regression analysis was performed to examine the factorsassociated Congenital anomalies. The results of logistic regression reported as adjusted oddsrations (OR) with 95% confidence intervals and p-value < 0.05 are considered statistically significant. Results: An analysis involving 131 cases and 128 controls revealed that the median age ofmothers stood at 28(±IQR= 6) years. Respiratory anomalies were identified as the most common,accounting for 21.4 % of the cases, followed by multiple congenital anomalies at 20.6 %, andgastrointestinal anomalies at 19.8 % of cases. After adjusting for all variablesinthemultivariate analysis, folic acid supplementation was found to have a significant impact on preventingcongenital anomalies (AOR=0.58, 95% CI 0.3, 0.99, p=0.032). Further analysis of the datarevealed that maternal age over 35 years (AOR=2.3, 95% CI 0.8, 6.5, p=0.12), maternal smoking(AOR=6.7, 95% CI 0.8, 58.1, p=0.08), a history of previous congenital anomalies (AOR=2.1,95% CI 0.4, 11.8, p=0.4), exposure to environmental toxins (AOR=0.2, 95% CI 0.3, 3.8,p=0.78), maternal alcohol consumption (AOR=2.4, 95% CI 0.6, 9.6, p=0.21),and maternalchronic medical conditions (AOR=1.8, 95% CI 0.7, 4.4, p=0.23) were non-statistical positiveassociation with congenital anomalies. Conclusion: Numerous factors have been linked to the occurrence ofcongenital anomalies. Thepattern of these anomalies differed from those found in other local studies and global evidence,despite similar contributing and aggravating factors. | |
| dc.identifier.uri | https://etd.aau.edu.et/handle/123456789/6352 | |
| dc.language.iso | en_US | |
| dc.publisher | Addis Ababa University | |
| dc.subject | Congenital Anomalies NICU Neonates | |
| dc.title | Pattern and Factors Associated with Congenital Anomalies among NICU Admitted Neonates in TASH: Case-Control study | |
| dc.type | Thesis |